Skip to main content

2 Result(s)

within Masayoshi Kawata Remove this filter

and

  1. Article

    Open Access

    Development of extended pharmacokinetic models for propofol based on measured blood and brain concentrations

    Propofol’s pharmacokinetics have been extensively studied using human blood samples and applied to target-controlled infusion systems; however, information on its concentration in the brain remains scarce. The...

    Masayoshi Kawata, Atsushi Yonezawa, Yohei Mineharu, Kotaro Itohara… in Scientific Reports (2024)

    Download PDF (4143 KB) View Article

  2. No Access

    Article

    Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of l-dopa and its metabolite 3-O-methyldopa in combination with entacapone

    In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing...

    Joe Yamamoto, Tomohiro Omura, Sachiko Kasamo… in Journal of Neural Transmission (2021)