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Article
Open AccessHepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation
Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functi...
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Article
Open AccessPivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis
DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S-adenosyl-l-methionine. Methylation regulates gene expression, serving a variety of physiological and pathophysiological ro...
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Article
Non-density of Points of Small Arithmetic Degrees
Given a surjective endomorphism \(f: X \rightarrow X\) f : ...
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Article
Open AccessHistone functions as a cell-surface receptor for AGEs
Reducing sugars can covalently react with proteins to generate a heterogeneous and complex group of compounds called advanced glycation end products (AGEs). AGEs are generally considered as pathogenic molecule...
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Article
Open AccessCurrent progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review
Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic ef...
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Article
Open AccessLow temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified
Low-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed as potential cancer therapeutic reagents. We p...
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Article
Map** replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing
Replication timing (RT) domains are stable units of chromosome structure that are regulated in the context of development and disease. Conventional genome-wide RT map** methods require many S-phase cells for...
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Article
Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide
Stylissatin A (SA) is a cyclic heptapeptide isolated from the marine sponge Stylissa massa. SA shows anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells, but th...
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Article
Genome-wide stability of the DNA replication program in single mammalian cells
Here, we report a single-cell DNA replication sequencing method, scRepli-seq, a genome-wide methodology that measures copy number differences between replicated and unreplicated DNA. Using scRepli-seq, we demo...
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Article
Arithmetic degrees for dynamical systems over function fields of characteristic zero
We study the arithmetic degree of a dominant rational self-map on a smooth projective variety over a function field of characteristic zero. We interpret the notion of arithmetic degree and study related proble...
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Article
Open AccessStructural and functional insights into S-thiolation of human serum albumins
Human serum albumin (HSA) is the most abundant serum protein, contributing to the maintenance of redox balance in the extracellular fluids. One single free cysteine residue at position 34 is believed to be a t...
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Article
Open AccessDisruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke
The extent to which defective innate immune responses contribute to chronic obstructive pulmonary disease (COPD) is not fully understood. Pulmonary surfactant protein A (SP-A) plays an important role in regula...
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Article
Open AccessIdentification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein
Pyrroloquinoline quinone (PQQ), a redox-active o-quinone, is an important nutrient involved in numerous physiological and biochemical processes in mammals. Despite such beneficial functions, the underlying molecu...
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Article
Open AccessIdentification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel
Mast cells play important roles in allergic inflammation by secreting various mediators. In the present study, based on the finding that the medium conditioned by activated RBL-2H3 mast cells enhanced the nerv...
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Article
Open AccessLysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins
Covalent modification of proteins exerts significant effects on their chemical properties and has important functional and regulatory consequences. We now report the identification and verification of an elect...
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Article
Open AccessInflammatory pseudotumor of the liver diagnosed as metastatic liver tumor in a patient with a gastrointestinal stromal tumor of the rectum: report of a case
Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion. A case of IPT of the liver found in association with a malignant gastrointestinal stromal tumor (GIST) is reported.
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Article
Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats
Early detection and prevention is an important goal in acute respiratory distress syndrome research. We determined the concentration of the anti-inflammatory 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) and other ...
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Article
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration
Hydrogen sulfide anion reacts with cellular electrophiles, including 8-nitro-cGMP, and sulfhydration products inhibit S-guanylation–dependent H-Ras activation in cardiac inflammatory injury models. ...
