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Article
Open AccessDistinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors
We have previously reported that 12p gain may predict the presence of malignant components and poor prognosis for CNS germ cell tumor (GCT). Recently, 3p25.3 gain was identified as an independent predictor of ...
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Article
An international study evaluating the epidemiology of intracranial germ cell tumors in the native versus immigrant Japanese populations: the need for an international registry
Pediatric intra-cranial germ cell tumors (iGCTs) occur at an incidence of 0.6–1.2 cases/million/year in Western countries. The incidence is reported up to 5 times higher in Japan. It is unknown whether this in...
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Article
Employment status and termination among survivors of pediatric brain tumors: a cross-sectional survey
Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors’ employment status.
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Article
Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas
Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conv...
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Article
Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma
This trial was designed to evaluate the safety and clinical responses to a combination of temozolomide (TMZ) chemotherapy and immunotherapy with fusions of DCs and glioma cells in patients with glioblastoma (G...
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Article
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy
Germ cell tumors constitute a heterogeneous group that displays a broad spectrum of morphology. They often arise in testes; however, extragonadal occurrence, in particular brain, is not uncommon, and whether t...
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Article
Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors
Human chorionic gonadotropin (hCG) production has been utilized as a diagnostic marker for germinoma with syncytiotrophoblastic giant cells (STGC) and choriocarcinoma. Elevated hCG in germinoma is considered t...
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Article
Brainstem oligodendroglial tumors in children: two case reports and review of literatures
There is little information on pediatric oligodendroglial tumor located in the brainstem because of its rarity.
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Article
Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas
Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 15 in Japan. The pathogenesis of iGCTs is largely unexplored. Although a subset of iGCTs is known to have KIT mut...
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Article
Cancer-specific health-related quality of life in children with brain tumors
To understand the influence of disease and treatment on the health-related quality of life (HRQOL) of children with brain tumors, compared to the HRQOL of children with other cancers, from the viewpoints of ch...
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Article
Factors influencing self- and parent-reporting health-related quality of life in children with brain tumors
Health-related quality of life (HRQOL) is not only a degree of health but also reflects patient perceptions and expectations of health. For children with brain tumors, better understanding of HRQOL requires th...
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Article
Pineal parenchymal tumor of intermediate differentiation with marked elevation of MIB-1 labeling index
We report a case of pineal parenchymal tumor (PPT) in an 11-year-old girl. Brain magnetic resonance imaging (MRI) revealed a large tumor (48 mm) located in the pineal region with heterogeneous enhancement afte...
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Article
Effect of single-dose amoxicillin on rat incisor odontogenesis: a morphological study
The effect of exposure to amoxicillin on tooth development remains to be elucidated. The purpose of this study was to investigate the effect of amoxicillin on rat incisor odontogenesis. Male Wistar rats weighi...
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Article
O 6-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment
Favorable responses to temozolomide chemotherapy have recently been reported in primary central nervous system lymphoma (PCNSL) patients who are refractory to high-dose methotrexate therapy. The gene encoding ...
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Article
Immunolocalization of TAK1, TAB1, and p38 in the develo** rat molar
In tooth development, transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) are involved in cell differentiation and matrix protein production. TGF-β and BMP have two signaling pathways:...
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Article
Transforming growth factor beta inducible apoptotic cascade in epithelial cells during rat molar tooth eruptions
In tooth eruptions, the presence of apoptotic epithelial cells at the eruption site has been reported, but the factors that induce apoptosis in these cells remain to be elucidated, as do the induction pathways...
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Article
Open AccessDevelopment of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module
The Pediatric Quality of Life Inventory™ (PedsQL™) is a widely-used modular instrument for measuring health-related quality of life in children aged 2 to 18 years. The PedsQL™ Brain Tumor Module is comprised o...
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Diffuse Intrinsic Pontine Gliomas
Brain stem tumors account for 10–15% of all primary childhood CNS tumors. Most of the brain tumors arising in the brain stem are gliomas. With recent advances in neuro-imaging, particularly the advent of magne...
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Article
Apatite crystal in hard tissue of conodont fossils
The present study was aimed at examining the nature of apatite crystal in the tooth apparatus of a conodont fossil using transmission electron microscopy (TEM), scanning electron microscopy (SEM), laser Raman ...
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Article
Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma
Cadherins are Ca2+-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently ...
