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  1. No Access

    Article

    Intracellular generation of single-strand template increases the knock-in efficiency by combining CRISPR/Cas9 with AAV

    Targeted integration of transgenes facilitates functional genomic research and holds prospect for gene therapy. The established microhomology-mediated end-joining (MMEJ)-based strategy leads to the precise gen...

    Qing **ao, Taishan Min, Shuang** Ma, Lingna Hu… in Molecular Genetics and Genomics (2018)

  2. No Access

    Article

    CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice

    Hemophilia B (HB) is an X-linked disorder caused by defects of F9 encoded coagulation factor IX, which is an ideal model for gene therapy. Most existing HB gene therapies are based on viral mediated gene suppleme...

    Cong Huai, Chenqiang Jia, Ruilin Sun, Peipei Xu, Taishan Min, Qihan Wang… in Human Genetics (2017)

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    Article

    esiRNAs purified with chromatography suppress homologous gene expression with high efficiency and specificity

    Many preclinical studies have shown RNA interference (RNAi) as a new promising way to treat various human diseases including cancer and virus infection and there is an increasing demand for the large-scale pre...

    Baoqin Xuan, Zhikang Qian, Chang Tan, Taishan Min, Shuiyuan Shen… in Molecular Biotechnology (2005)

  4. No Access

    Article

    Cloning of an alkaline lipase gene from Penicillium cyclopium and its expression in Escherichia coli

    The gene encoding an alkaline lipase of Penicillium cyclopium PG37 was cloned with four steps of PCR amplification based on different principles. The cloned gene was 1,480 nucleotides in length, consisted of 94 b...

    Minchen Wu, Zhikang Qian, Peihong Jiang, Taishan Min, Chongrong Sun, Weida Huang in Lipids (2003)