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Article
Associations of soy product intake with all-cause, cardiovascular disease and cancer mortality: Guangzhou Biobank Cohort Study and updated meta-analyses
We examined the associations of soy product intake with all-cause, cardiovascular disease (CVD), and cancer mortality and mediations through CVD risk factors based on the Guangzhou Biobank Cohort Study (GBCS),...
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Article
Open AccessAssociation of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study
To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was us...
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Article
Open AccessEffectiveness of Instant Messaging-Based Online Group Support for Preventing Smoking Relapse: a Pragmatic Randomized Controlled Trial
Online group support potentially help prevent smoking relapse. This two-arm, pragmatic, open-label randomized controlled trial assessed the effectiveness of instant messaging (IM) (i.e., WhatsApp) online group...
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Article
Open AccessAssociations of daytime nap** and nighttime sleep quality with depressive symptoms in older Chinese: the Guangzhou biobank cohort study
Poor sleep quality has been linked to depression in older adults, but results of the association between daytime nap** and depression remains limited and conflicting. Moreover, whether the association of day...
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Article
Cereal intake and mortality in older Chinese: a 15-year follow-up of a prospective cohort study
We examined the association between whole grain and refined grain intake with all-cause, cancer and cardiovascular disease (CVD) mortality using the data from the Guangzhou Biobank Cohort Study.
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Article
Mendelian randomization on the association of obesity with vitamin D: Guangzhou Biobank Cohort Study
Mendelian randomization (MR) analyses from the West provide evidence that obesity causes lower 25-hydroxyvitamin D [25(OH)D]. As Asian populations are prone to metabolic disorders at a lower body mass index (B...
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Article
Open AccessCOVID-19 pandemic fatigue and its sociodemographic and psycho-behavioral correlates: a population-based cross-sectional study in Hong Kong
Pandemic fatigue is a growing public health concern of the lingering COVID-19 pandemic. Despite its widespread mass media coverage, systematic empirical investigations are scarce. Under the Hong Kong Jockey Cl...
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Article
Open AccessAdaptive interventions to optimise the mobile phone-based smoking cessation support: study protocol for a sequential, multiple assignment, randomised trial (SMART)
Mobile health (mHealth) is promising in develo** personalised smoking cessation interventions. By using an adaptive trial design, we aim to evaluate the effectiveness of personalised mHealth intervention in ...
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Article
Open AccessAdversity co** capability and its associations with mental health and family wellbeing amid the COVID-19 pandemic in Hong Kong
Adversity co** capability (ACC) is important amid the COVID-19 pandemic. We examined the associations of ACC as measured by our one-item ACC scale (ACC-1) with mental health, family well-being and validity o...
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Article
Open AccessAssociations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study
Although social isolation has been associated with a higher mortality risk, little is known about the potential different impacts of face-to-face and non-face-to-face isolation on mortality. We examined the pr...
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Article
Open AccessA polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association stu...
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Article
A Simple Model for Predicting 10-Year Cardiovascular Risk in Middle-Aged to Older Chinese: Guangzhou Biobank Cohort Study
The aim of this paper is to develop 10-year cardiovascular disease (CVD) risk prediction models for the contemporary Chinese populations based on the Guangzhou Biobank Cohort Study (GBCS) and to compare its pe...
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Article
Association of fish consumption with risk of all-cause and cardiovascular disease mortality: an 11-year follow-up of the Guangzhou Biobank Cohort Study
Whether fish consumption is associated with all-cause, cardiovascular (CVD), ischemic heart disease (IHD) and stroke mortality remains inconclusive. We examined the association of fish consumption with all-cau...
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Article
Open AccessMendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control
Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serologica...
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Article
Open AccessObesity indicators as mediators of association between daytime nap** and type 2 diabetes mellitus: the Guangzhou Biobank Cohort Study
To examine the mediating effect of obesity indicators on the association between daytime nap** and type 2 diabetes mellitus (T2DM) qualitatively and quantitatively using baseline data from the Guangzhou Biob...
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Article
Open AccessLate-onset or chronic overweight/obesity predicts low self-esteem in early adolescence: a longitudinal cohort study
How weight status changes with time may affect self-esteem was seldom studied. We identified the distinct trajectories of overweight/obesity over age and assessed their associations with different domains of s...
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Article
Open AccessCharacterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma
Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy that has been etiologically linked to Epstein-Barr virus (EBV) infection, with EBV gene transcripts identified in almost all cases....
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Article
Open AccessBrain-derived neurotrophic factor gene variants and obesity in former smokers
From genome-wide association studies, brain-derived neurotrophic factor (BDNF) locus on chromosome 11 was the only SNP associated with both smoking and body mass index (BMI) in European, African and Asian populat...
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Article
Open AccessUse patterns of cigarettes and alternative tobacco products and socioeconomic correlates in Hong Kong secondary school students
Smoking is a major cause of health inequities. However, sociodemographic differences in adolescent tobacco use are unclear. In a territory-wide school-based anonymous survey in 2018/19, we investigated tobacco...
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Article
Open AccessIdentification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies ...
