87 Result(s)
within
Tae-** Jeong
Biomedicine, general
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Article
Evaluation of a spray-dried amorphous solid dispersion formulation of ID11916, a new molecular entity with dual inhibition mechanisms targeting the androgen receptor and phosphodiesterase type-5
The objective of this study is to develop an amorphous solid dispersion (ASD) formulation that enhances the oral bioavailability of ID11916, a novel molecular entity with dual inhibition mechanisms targeting t...
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Open AccessCorrection: TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
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Open AccessCorrection: Inflammation promotes synucleinopathy propagation
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Open AccessTubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1
Tumor cells of diffuse-type gastric cancer (DGC) are discohesive and infiltrate into the stroma as single cells or small subgroups, so the stroma significantly impacts DGC progression. Cancer-associated fibrob...
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Open AccessComparison between the mesenteric fixation method (MEFIX) and conventional methods at preventing the occurrence of Petersen’s hernia: a study protocol for a multicenter randomized controlled trial
Petersen’s hernia, which occurs after Billroth-II (B-II) or Roux-en-Y (REY) anastomosis, can be reduced by defect closure. This study aims to compare the incidence of bowel obstruction above Clavien–Dindo clas...
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Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia
The objective of this study was to design a fixed-dose combination (FDC) tablet with minimal interaction of valsartan, amlodipine, rosuvastatin and ezetimibe to improve medication compliance in patients with h...
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Open AccessCancer signature ensemble integrating cfDNA methylation, copy number, and fragmentation facilitates multi-cancer early detection
Cell-free DNA (cfDNA) sequencing has demonstrated great potential for early cancer detection. However, most large-scale studies have focused only on either targeted methylation sites or whole-genome sequencing...
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Open AccessPersonalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer
Postoperative minimal residual disease (MRD) detection using circulating-tumour DNA (ctDNA) requires a highly sensitive analysis platform. We have developed a tumour-informed, hybrid-capture ctDNA sequencing M...
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Ultrafast prediction of somatic structural variations by filtering out reads matched to pan-genome k-mer sets
Variant callers typically produce massive numbers of false positives for structural variations, such as cancer-relevant copy-number alterations and fusion genes resulting from genome rearrangements. Here we de...
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Article
Open AccessInflammation promotes synucleinopathy propagation
The clinical progression of neurodegenerative diseases correlates with the spread of proteinopathy in the brain. The current understanding of the mechanism of proteinopathy spread is far from complete. Here, w...
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Dynamic changes in longitudinal circulating tumour DNA profile during metastatic colorectal cancer treatment
Circulating tumour DNA (ctDNA) has been spotlighted as an attractive biomarker because of its easy accessibility and real-time representation of tumour genetic profile. However, the clinical utility of longitu...
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Open AccessMitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure
Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been ...
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Open AccessTNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis
Cell-to-cell propagation of α-synuclein is thought to be the underlying mechanism of Parkinson’s disease progression. Recent evidence suggests that inflammation plays an important role in the propagation of pr...
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Open AccessFecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency
Despite the strong influence of the gut microbiota on atherosclerosis, a causal relationship between atherosclerosis pathophysiology and gut microbiota is still unverified. This study was performed to determin...
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Open AccessSurvival impact of additional chemotherapy after adjuvant concurrent chemoradiation in patients with early cervical cancer who underwent radical hysterectomy
To determine whether additional chemotherapy after concurrent chemoradiation (CCRT) improves survival outcomes in patients with early cervical cancer who undergo radical hysterectomy (RH).
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Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands
The miniaturization and high integration of devices demand significant thermal management materials. Current technologies for the thermal management of electronics show some limitations in the case of multiple...
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Open AccessTrastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data
Since the results of the ToGA trial were published, trastuzumab-based chemotherapy has been used as the standard first-line treatment for HER2-positive recurrent or primary metastatic gastric cancer (RPMGC). H...
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Open AccessDynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis
We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis.
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Open Accessβ-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis
Adenomyosis is defined as the presence of ectopic nests of endometrial glands and stroma within the myometrium. Adenomyosis is a common cause of dysmenorrhea, menorrhagia, and chronic pelvic pain but is often ...
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Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer
The epidermal growth factor receptor (EGFR) pathway plays an important role in the progression of colorectal cancer (CRC). Anti-EGFR drugs based on antibodies have been widely used for treating CRC through ind...
