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Article
Identification of Mad as a repressor of the human telomerase (hTERT) gene
Activation of telomerase, which has been frequently associated with cellular immortality, may constitute a key step in the development of human cancer. De-repression in the expression of its catalytic subunit ...
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Protocol
Histone Modifications and Transcription Factor Binding on Chromatin: ChIP–PCR Assays
Chromatin, the eukaryotic template of genetic information, is subject to a diverse array of posttranslational modifications that largely im**e on the N-termini of histones, such as acetylation, methylation, ...
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Article
Small molecule–based reversible reprogramming of cellular lifespan
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Article
Correction: Corrigendum: Small molecule–based reversible reprogramming of cellular lifespan
Nature Chemical Biology 2, 369–374 (2006); published online 11 June 2006; corrected after print 22 December 2006 In the version of this article initially published, no competing financial interests were declar...
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Article
Retraction Note: Small molecule–based reversible reprogramming of cellular lifespan
In this paper, we described the application of magnetism-based interaction capture (MAGIC) to find a small-molecule protein target. MAGIC identified the protein ATM as the target of CGK733, a small molecule re...