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  1. No Access

    Article

    Methoxyflavones isolated from the whole plant of Scutellaria rubropunctata Hayata var. rubropunctata promote osteoblast differentiation in MC3T3-E1 cells

    In this study, we isolated two new methoxyflavones (1 and 2) and eight known methoxyflavones (3–10) from the whole plant of Scutellaria rubropunctata Hayata var. rubropunctata (SR). Based on spectroscopic analyse...

    Misaki Watanabe, Tadahiro Yahagi, Rina Kamikura… in Journal of Natural Medicines (2023)

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    Article

    17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1

    Homeobox A9 (HOXA9) is a transcription factor that is overexpressed in acute myeloid leukemia (AML). It is associated with the pathogenesis and progression of AML, and is a factor responsible for a poor progno...

    Shohei Takase, Young Sook Yun, Fuki Moriya, Saaya Sekine… in Journal of Natural Medicines (2023)

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    Article

    Quality evaluation of Pinellia tuber by LC-TOF/MS targeted to ephedrine

    Pinellia tuber (PTE, 半夏, 大半夏, 掌葉半夏, 天南星, 水半夏, 半夏瀉心湯, 半夏厚朴湯, 六君子湯) is derived from the tuber of Pinellia ternata Breitenbach (Araceae), which is a crude drug used in traditional Japanese Kampo medicine for the pur...

    Tadahiro Yahagi, Toshiyuki Atsumi, Shuichirou Mano… in Journal of Natural Medicines (2021)

  4. No Access

    Article

    Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms

    Pancreatic cancer is a lethal disease with a very poor prognosis. Recent reports indicate that hypoxia signaling mediated by hypoxia-inducible factor (HIF) contributes to the progression of pancreatic cancer. ...

    Hiroaki Yahagi, Tadahiro Yahagi, Miki Matsumura… in Journal of Natural Medicines (2021)

  5. No Access

    Article

    Sinomenine and magnoflorine, major constituents of Sinomeni Caulis et Rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes

    The effects of the water extract of Sinomeni Caulis et Rhizoma (SCR-WE) and its major constituents, sinomenine (SIN) and magnoflorine (MAG), on moderate hemolysis induced by lysophosphatidylcholine (LPC) were inv...

    Hitoshi Sakumoto, Yumiko Yokota, Gakushi Ishibashi… in Journal of Natural Medicines (2015)

  6. Article

    Open Access

    Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells

    We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitr...

    Tadahiro Yahagi, Naoyuki Yakura, Keiichi Matsuzaki… in Journal of Natural Medicines (2014)

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