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Article
Predicting response/resistance to endocrine therapy for breast cancer
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Article
Pathology results from the UK Age Trial
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Article
Primary systemic therapy for operable breast cancer - 10-year survival data after chemotherapy and hormone therapy
Between 1984 and 1990, 94 women presenting to the Edinburgh Breast Unit with operable breast cancer of 4 cm or greater in diameter (T2, T3, N0, N1, M0) were given preoperative systemic therapy. Initially, all ...
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Article
The Edinburgh randomised trial of breast cancer screening: results after 10 years of follow-up
The Edinburgh Randomised Trial of Breast Cancer Screening recruited 44,288 women aged 45-64 years into the initial cohort of the trial during 1978-81, and 10 years of follow-up is now complete. A total of 22,9...
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Article
Critical determination of the frequency of c-erbB-2 amplification in breast cancer
Tissues from 323 methacarn-fixed and paraffin-embedded breast cancers were assessed for c-erbB-2 gene amplification by differential polymerase chain reaction (dPCR). The sensitivity of dPCR was ascertained usi...
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Article
Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast
Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system...
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Article
Ras p21 in breast tissue: associations with pathology and cellular localisation
Immunocytochemistry with monoclonal antibody Y13-259 demonstrated p21 ras in paraffin sections of breast tissue from 171 women: 85 with invasive breast carcinoma, 14 with non-invasive carcinoma and 72 with ben...
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Article
Comparative pathology of breast cancer in a randomised trial of screening
In the Edinburgh Randomised Breast Screening Project (EBSP) to December 1988 there were 500 cancers in the study population invited to screening and 340 cancers identified in the control population. The size a...
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Article
Primary systemic therapy for operable breast cancer
Eighty-eight patients presenting with operable breast cancer of 4 cm or greater in diameter (T2, T3, N0, N1, M0) have received primary systemic therapy. Response was assessed following 12 weeks of systemic the...
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Article
The relevance of control histology in oestrogen receptor estimation
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Article
DNA analysis of breast tumour fine needle aspirates using flow cytometry
Cellular DNA was analysed by flow cytometry in fine needles aspirates (FNA) from both benign and malignant breast lesions in order to determine the feasibility of flow cytometric analysis. In 22 of 26 (84%) be...