4 Result(s)
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Article
Nesfatin-1 ameliorates type-2 diabetes-associated reproductive dysfunction in male mice
The present study was aimed to demonstrate the recuperative effect of nesfatin-1 on testicular dysfunction in the high-fat diet (HFD)/streptozotocin (STZ)-induced type-2 diabetes mellitus (T2DM) mice.
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Article
Open AccessIncreased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy me...
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Article
IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin
Obesity and metabolic syndrome are the major risk factors for cardiovascular disease. Obesity is caused by increased food intake and/or decreased energy expenditure. Leptin potently inhibits food intake and pr...
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Article
Open AccessPotentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortal...
