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Article
Space weathering record and pristine state of Ryugu samples from MicrOmega spectral analysis
The samples returned from asteroid Ryugu were collected both at its surface and at its subsurface by Hayabusa2 and can, thus, provide information on the space weathering of C-type asteroids at different depths...
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Article
Constraints on Solar System early evolution by MicrOmega analysis of Ryugu carbonates
The samples returned from a C-type asteroid (Ryugu) by the Hayabusa2 mission constitute unprecedented access to carbonaceous material never exposed to Earth’s atmosphere that may still contain phases formed in...
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Article
First compositional analysis of Ryugu samples by the MicrOmega hyperspectral microscope
The characterization of objects that have best preserved the mineralogical and molecular phases formed in the earliest stages of the Solar System evolution is key to understanding the processes that led to the...
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Article
Nesfatin-1 ameliorates type-2 diabetes-associated reproductive dysfunction in male mice
The present study was aimed to demonstrate the recuperative effect of nesfatin-1 on testicular dysfunction in the high-fat diet (HFD)/streptozotocin (STZ)-induced type-2 diabetes mellitus (T2DM) mice.
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Article
Open AccessThermal and impact histories of 25143 Itokawa recorded in Hayabusa particles
Understanding the origin and evolution of near-Earth asteroids (NEAs) is an issue of scientific interest and practical importance because NEAs are potentially hazardous to the Earth. However, when and how NEAs...
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Article
Open AccessIncreased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy me...
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Article
IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin
Obesity and metabolic syndrome are the major risk factors for cardiovascular disease. Obesity is caused by increased food intake and/or decreased energy expenditure. Leptin potently inhibits food intake and pr...
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Article
Physiological and molecular endocrine changes in maturing wild sockeye salmon, Oncorhynchus nerka, during ocean and river migration
Maturing adult sockeye salmon Oncorhynchus nerka were intercepted while migrating in the ocean and upstream in freshwater over a combined distance of more than 1,300 km to determine physiological and endocrine ch...
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Article
Open AccessPotentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortal...
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Article
Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control
Hyperlipidaemia often occurs in patients with type 2 diabetes mellitus. Though HMG-CoA reductase inhibitors (statins) are widely used for controlling hypercholesterolemia, atorvastatin has also been reported t...
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Salmon gonadotropes secrete free form alpha (α)-subunit: quantitative analysis by the sandwich cell immunoblot assay
The sandwich cell immunoblot assay confirmed that salmon LH-cells secreted the free form α-subunit along with the dimeric LH, but lower in amounts than the LH.
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Chapter
PACAP Receptor Signaling
PACAP receptors have been identified in different tissues (Lam et al, 1990; Cauvin et al, 1991; Gottschall et al, 1991; Shivers et al, 1991; Tatsuno et al, 1991; Masuo et al, 1992) and three different types have ...
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Article
Stimulation of insulin-like growth factor-I production by recombinant bovine growth hormone in Mozambique tilapia, Oreochromis mossambicus
We have previously reported growth-promoting effects of recombinant bovine growth hormone (rbGH) in Mozambique tilapia, Oreochromis mossambicus, after 4 weekly injections or a single injection of slow-releasing f...
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Article
The DNA sequence of human chromosome 21
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. S...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6
We examined the relationship between cytosolic Ca2+ concentration ([Ca2+]c) and mitochondrial matrix Ca2+ concentration ([Ca2+]m) in the pancreatic beta-cell line, MIN6. [Ca2+]c was monitored in a single or a gr...
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Article
Pb-based ferroelectric thin film actuator for optical applications
Novel PZT thin film actuators for optical applications were proposed. Key issues for realizing the actuators such as PZT thin film processes, mechanical properties evaluation of thin films, and design for lami...
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Chapter
Mechanics of Intramural Blood Vessels of the Beating Heart
The blood flow of the coronary circulation is unique in that it supplies blood to the myocardium which pumps blood into the systemic and pulmonary circulations. In 1628, Harvey (1) found that the heart is a pu...
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Article
Residual stress analysis of joints of ceramics and metals
Development of reliable bonding techniques for ceramics and metals is considered to be very important for more useful applications of ceramics to machinery parts. However, a high thermal stress concentration o...
