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Open AccessReal-world treatment patterns and outcomes of abemaciclib for the treatment of HR + , HER2- metastatic breast cancer patients in Japan
This study described, in routine clinical practice in Japan, the patient characteristics, treatment patterns, and outcomes of female patients with HR + /HER2- metastatic breast cancer (MBC) who started abemaci...
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Open AccessEfficacy and safety of trastuzumab, lapatinib, and paclitaxel neoadjuvant treatment with or without prolonged exposure to anti-HER2 therapy, and with or without hormone therapy for HER2-positive primary breast cancer: a randomised, five-arm, multicentre, open-label phase II trial
Dual blockade of HER2 promises increased pathological complete response (pCR) rate compared with single blockade in the presence of chemotherapy for HER2-positive (+) primary breast cancer. Many questions rema...
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Article
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis
Astrocytes are known to facilitate repair following brain injury; however, little is known about how injured astrocytes repair themselves. Repair of cell membrane injury requires Ca2+-triggered vesicle exocytosis...
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Article
Open AccessEarly and mid-term results of transapical and right axillary artery cannulation for acute aortic dissection
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Open AccessAortic regurgitation and aortic valve replacement during repair of acute aortic dissection
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Open AccessEarly results of aortic root reoperation
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Open AccessCytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly h...
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Article
Open AccessBRAFV600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas
Frequency of a BRAFV600E mutation in anaplastic thyroid carcinoma, which is thought to be derived mainly from papillary carcinoma by multi-step carcinogenesis, is much lower than that in papillary carcinomas. To ...
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Article
Open AccessClinical outcome and risk factors for recurrence in borderline ovarian tumours
We investigated the long-term prognosis of borderline ovarian tumours and determined risk factors for recurrence. One hundred and twenty-one borderline ovarian tumours treated between 1994 and 2003 at the part...
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Open AccessHigh-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas
To find mRNAs whose expression differs between thyroid follicular adenomas and carcinomas, a high-throughput analysis of mRNAs in these two tumours was performed. This method, named high-throughput differentia...
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Article
A novel apolipoprotein E5 variant with a 24-bp insertion causing hyperlipidemia
A tandem 24-bp insertion in the apolipoprotein E (apo E) gene was detected in a patient with elevated triglyceride, apolipoprotein (apo) CII, and apo CIII levels. This novel variant, apo E5ss, showed in position...
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Open AccessQuantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy
Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated t...
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Open AccessGene expression profiles in thyroid carcinomas
The gene expression profiles of human thyroid carcinomas were analysed by serial analysis of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More th...