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Article
Differences in insulin sensitivity and risk markers due to gender and age in hypertensives
Men run a higher risk for cardiovascular disease than women, even if hypertensive. This has been attributed to a more pronounced central (abdominal) fat distribution in men as well as menopausal state in women...
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Article
Effects of hydrochlorothiazide and captopril on lipoprotein lipid composition in patients with essential hypertension
Objective: Effective antihypertensive agents may differ in their capacity to reduce cardiovascular risk because they induce potentially atherogenic alterations in lipoprotein composition.
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Article
On the interplay beween insulin secretion and sensitivity as determinants of glucose tolerance
Both insulin secretion and sensitivity have been claimed to be the main characteristics in the determination of future detoriation in glucose tolerance. In this cross-sectional study insulin secretion and insu...
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Article
The sympathetic response to euglycaemic hyperinsulinaemia
Sympathetic nervous system activation by insulin has been suggested as a mechanism explaining the association between insulin resistance and hypertension. We further examined the effect of insulin by direct mi...
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Article
Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had ...
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Article
Screening for insulin receptor gene DNA polymorphisms associated with glucose intolerance in a Scandinavian population
The significance of insulin receptor gene variants in the aetiology of Type 2 (non-insulin-dependent) diabetes mellitus has been investigated by analysis of restriction fragment length polymorphisms in a genet...
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Article
Characterisation of insulin-like growth factor I receptor in skeletal muscles of normal and insulin resistant subjects
The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and te...
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Article
Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension
The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, a...
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Article
Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and Type 2 (non-insulin-dependent) diabetes mellitus
The tyrosine kinase activity of the insulin receptor was investigated in skeletal muscle biopsies from insulin-resistant males with obesity or with Type 2 (non-insulin-dependent) diabetic males who were lean o...
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Chapter
Effects of Diet Fat Composition on Serum Lipids and Lipoproteins in Patients with Insulin-Dependent Diabetes Mellitus
In several countries general recommendations have been made concerning the fat content of the diet of patients with insulin-dependent diabetes mellitus (IDDM) [1–3]. A low total fat content (below 30–35 energy...
