4 Result(s)

Article

MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents

The cornea plays an important role in transmitting light and providing protection to the eye, but is susceptible to injury and infection. Standard treatments for corneal wounds include topical lubricants, anti...

Heather L. Chandler, Tao Tan, Chunlin Yang… in Communications Biology (2019)

Article

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue injury-repair and...

Zehua Bian, Qiang Wang, **nyu Zhou, Tao Tan, Ki Ho Park… in Nature Communications (2019)

Article

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific TRIM protein. Here we show...

Matthew Sermersheim, Adam D. Kenney, Pei-Hui Lin… in Nature Communications (2020)

Article

C1 Esterase Inhibition: Targeting Multiple Systems in COVID-19

T. M. Ayodele Adesanya, Courtney M. Campbell, Lijun Cheng… in Journal of Clinical Immunology (2021)