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Chapter and Conference Paper
Generating Polygons with Triangles
A set of triangles \(\mathcal F\) is said to generate a polygon ...
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Chapter and Conference Paper
Gastric Lymph Node Cancer Detection Using Multiple Features Support Vector Machine for Pathology Diagnosis Support System
In this paper, an automatic cancer detection method that combines multiple features to support pathologists is presented. Cancer is the most cause of death in Japan, and patients suffering with and who die of ...
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Article
Protective effects of nef-deleted SHIV or that having IFN-γ against disease induced with a pathogenic virus early after vaccination
To clarify the involvement of primitive non-specific immune responses in the protective effects of a live, attenuated virus, each two rhesus macaques were intravenously immunized with an attenuated chimeric si...
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Article
The quantity and diversity of infectious viruses in various tissues of SHIV-infected monkeys at the early and AIDS stages
To detect the major sites of viral replication in immunodeficiency virus-infected individuals, we quantified proviral DNA and infectious viruses using quantitative PCR and a plaque assay, respectively, in vari...
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Article
Augmentation of antigen-specific cytokine responses in the early phase of vaccination with a live-attenuated simian/human immunodeficiency chimeric virus expressing IFN-γ
A nef-deleted SHIV-NM-3rN (SHIV-NI) was previously shown to be nonpathogenic and to induce protective immunity. In the present study, a SHIV-NI expressing human interferon-γ (SHIV-IFN-γ) was constructed and th...
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Article
Infection of macaques with chimeric simian and human immunodeficiency viruses containing Env from subtype F
Chimeric simian and human immunodeficiency viruses (SHIVs) are useful for investigating the pathogenicity of human immunodeficiency virus (HIV-1) and to develop an anti-HIV-1 vaccine. We attempted to construc...
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Article
Characterization of simian and human immunodeficiency chimeric viruses re-isolated from vaccinated macaque monkeys after challenge infection
Monkeys that have been vaccinated with nef-deleted SHIVs were either fully or partially protected against challenge with acute pathogenic SHIV-89.6 P. Viruses isolated from these vaccinated monkeys were all foun...
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Article
Construction of SIV/HIV-1 chimeric viruses having the IL-5 gene and determination of their ability to replicate and produce IL-5
During the progression of AIDS, there is a shift in abundance of immune cells from Th1-producing cells to Th2-producing cells. To determine whether this change might have an effect on HIV-1 replication in viv...
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Article
Gene-mutated HIV-1/SIV chimeric viruses as AIDS live attenuated vaccines for potential human use
To develop an AIDS vaccine for human use as well as a suitable animal model for AIDS research, we constructed a series of HIV-1/SIVmac chimeric viruses (SHIVs). We successfully generated a SHIV (designated as ...
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Article
Fas antigen expression and apoptosis of lymphocytes in macaques infected with simian immunodeficiency virus strain mac
To investigate the role of apoptosis in the pathogenesis of HIV infection we used macaques infected with simian immunodeficiency virus (SIV) as a primate model and examined the characteristics of the apoptosis...
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Article
Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes
To clarify whether regulatory cytokines inhibit hematopoiesis in patients with myelodysplastic syndromes (MDS), malignancies characterized by the formation of cytopenias despite the presence of cellular bone m...
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Article
Genetic complementation between replication-defective mutants of HIV-1 and SIVagm
To investigate the functional complementation of essential genes for virus growth between HIV-1 and SIVagm derived from African green monkeys, we co-transfected replication-defective molecular clones containin...
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Article
The effect of casein phosphopeptides on calcium utilization in young ovariectomized rats
The effect of casein phosphopeptides (CPPs) on Ca utilization in ovariectomized (OVX) rats was studied. A mixture of CPPs corresponding to the amino acid sequences 1–25 and 1–28 in the β-casein was isolated fr...
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Article
Bioavailabilities of calcium, phosphorus and magnesium from whey mineral complex in growing male rats
The bioavailabilities of Ca, P and Mg from whey mineral complex (WMC) were studied from the viewpoint of the mineral balance and bone properties in growing male rats and compared with bovine bone ash (BBA) and...
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Article
Detection of Mason-Pfizer monkey virus infection by syncytia formation of human cells doubly transformed by Rous sarcoma virus and simian virus 40
Human cells doubly transformed by Rous sarcoma virus and SV40 (RSb cells) formed syncytia by cocultivation with Mason-Pfizer monkey virus (MPMV)-producing cells. This cell fusion was blocked by anti-MPMV serum...
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Article
Virogenic properties of AKR mouse sarcoma cells induced by Rous sarcoma virus
Sarcomas were induced in AKR mice by Schmidt-Ruppin strain of Rous sarcoma virus (RSV). Sarcoma cells were passagedin vivo andin vitro, and their virogenicities were examined. They did not produce any infectious ...
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Article
Persistence of rous sarcoma virus genome in AKR mouse sarcoma cells resistant to chromomycin A3 and actinomycin D
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Article
Isolation of a variant strain of Rous sarcoma virus oncogenic for ducks and mammals
In contrast with the Schmidt-Ruppin strain of RSV, Bryan strains are not oncogenic for ducks. From the Bryan standard strain (BS-RSV) a variant virus oncogenic for ducks was isolated by passing BS-RSV through ...
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Article
Oncogenicity of a variant of Rous sarcoma virus, the 14(d)7 strain, in chickens and ducks
The duck-adapted variant of the Rous sarcoma virus, strain 14(d)7, is oncogenic in chickens and ducks to the same degree, and this even after passages in chickens, ducks or chick embryo-grafted hamsters. Heat-...
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Article
Studies on the infection of tumor cells by extraneous viruses
Characteristics of quinone-induced carcinoma and fructose-induced sarcoma were described from their susceptibility to neurotropic viruses. Fixed rabies virus did not propagate at all in either tumor. Since Col...
