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  1. No Access

    Article

    Maternal IgG avidity, IgM and ultrasound abnormalities: combined method to detect congenital cytomegalovirus infection with sequelae

    We used maternal immunoglobulin M (IgM), immunoglobulin G (IgG) avidity index (AI) and fetal ultrasonography (US) to effectively detect a congenital cytomegalovirus-infected fetus that would suffer neurologica...

    M Kaneko, H Sameshima, T Minematsu, K Kusumoto, A Yamauchi… in Journal of Perinatology (2013)

  2. No Access

    Article

    Characteristics of the spin-trap** reaction of a free radical derived from AAPH: further development of the ORAC-ESR assay

    The characteristics of the spin-trap** reaction in the oxygen radical absorbance capacity (ORAC)-electron spin resonance (ESR) assay were examined, focusing on the kind of spin traps. 2,2-Azobis(2-amidinopro...

    A. Nakajima, E. Matsuda, Y. Masuda, H. Sameshima… in Analytical and Bioanalytical Chemistry (2012)

  3. No Access

    Article

    Effect of Dissolved Oxygen on the Reduction of Stable Nitroxide by Ascorbic Acid: In Vitro Model for Acute Hypoxia Ischemia

    The reaction between 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM), which is a blood–brain-barrier (BBB) permeable stable cyclic nitroxide, and ascorbic acid was examined in a low dissolved ox...

    A. Nakajima, Y. Masuda, E. Matsuda, Y. Ueda, H. Sameshima… in Applied Magnetic Resonance (2011)

  4. No Access

    Article

    Absence of tyrosine kinase mutations in Japanese colorectal cancer patients

    Tyrosine kinases, which are important regulators of intracellular signal-transduction pathways, have mutated forms that are often associated with oncogenesis and are attractive targets for therapeutic interven...

    R-X Shao, N Kato, L-J Lin, R Muroyama, M Moriyama, T Ikenoue, H Watabe… in Oncogene (2007)

  5. No Access

    Article

    Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients

    A recent study revealed that the p110α (PIK3CA), catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is somatically mutated in many types of cancer. For example, PIK3CA is mutated in an estimated 35.6% of ...

    Y Tanaka, F Kanai, M Tada, Y Asaoka, B Guleng, A Jazag, M Ohta, T Ikenoue… in Oncogene (2006)

  6. No Access

    Article

    The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1

    Hepatitis B virus X protein (HBx) has many cellular functions and is a major factor in hepatitis and hepatocellular carcinoma caused by HBV infection. A proteomic approach was used to search for HBx-interactin...

    Y Tanaka, F Kanai, T Ichimura, K Tateishi, Y Asaoka, B Guleng, A Jazag, M Ohta… in Oncogene (2006)

  7. No Access

    Article

    Glial cell line-derived neurotrophic factor protects against ischemia/hypoxia-induced brain injury in neonatal rat

    Ischemic/hypoxic brain damage induced in 7-day-old rats was significantly attenuated in a dose-dependent manner by intracerebral injection of glial cell line-derived neurotrophic factor (GDNF; 2 or 4 μg) with...

    T. Ikeda, X. Y. **a, Y. X. **a, T. Ikenoue, B. Han, B. H. Choi in Acta Neuropathologica (2000)