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Article

Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain

Survival and proliferation of cancer cells are often associated with hyperactivity of the serine/threonine kinase, Akt. Herein, we show that prosurvival activity of Akt can be converted into prodeath activity ...

J-S Kim, B Ku, T-G Woo, A-Y Oh, Y-S Jung, Y-M Soh, J-H Yeom, K Lee… in Cell Death & Disease (2015)