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Article
Endothelial Dysfunction in Type 2 Diabetes Mellitus
Endothelial dysfunction is an imbalance in the production of vasodilator factors and when this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro-atherogenic effects. This resu...
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Article
Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus
The present work was aimed to study the association of one carbon genetic variants, hyperhomocysteinemia and oxidative stress markers, i.e., serum nitrite, plasma malondialdehyde (MDA) and glutathione (GSH) on...
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Article
Reference intervals for serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, Lp (a), apolipoprotein A-I, A-II, B, C-II, C-III, and E in healthy South Indians from Andhra Pradesh
The incidence of cardiovascular and cerebrovascular disease is steadily increasing in South East Asian countries including Indian sub continent. Many lipids, apolipoproteins and Lp (a) except HDL-C and apo A-I...
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Article
Whether western normative laboratory values used for clinical diagnosis are applicable to Indian population? An overview on reference interval
Reference Intervals denote normative values related to laboratory parameters/analytes used by diagnostic centers for clinical diagnosis. International guidelines recommend that every country must establish ref...
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Article
Tumour markers: An overview
Tumor Markers comprise a wide spectrum of biomacromolecules synthesized in excess concentration by a wide variety of neoplastic cells. The markers could be endogenous products of highly active metabolic malign...
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Article
Prostate specific antigen in patients of benign prostate hypertrophy and carcinoma prostate
Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the present study PSA was determined in serum of healthy subjects, patients of benign pr...
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Article
Stability of total and free prostate specific antigen in serum samples at different storage conditions
The present preliminary study was performed to find out stability of total prostate specific antigen (PSA) and free prostate specific antigen (FPSA) in serum of healthy males as well as in patients of benign a...
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Article
Racial and ethnic variation of PSA in global population: Age specific reference intervals for serum prostate specific antigen in healthy South Indian males
The serum PSA is universally accepted as the useful and clinically relevant tumor marker for monitoring therapy and identifying early recurrence in patients of carcinoma prostate throughout the world. However,...
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Article
Application of tumor markers in ovarian malignancies
Ovarian cancer is the fifth leading cause of death in women. The incidence of this malignancy increases in women over the age of 40. The overall five years survival is less than 30%, as most women present with...
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Article
Spectrum of monoclonal gammapathies in Andhra Pradesh
In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period of 1987 to 2000. The monoclonal band was identified in serum by agar gel electropho...
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Article
An overview of monoclonal gammapathies
The neoplastic proliferation of single clones of plasma cells causes synthesis of very large amount of monoclonal immunoglobulins consisting of only one type of heavy either the gamma, alpha, mu, delta or epsi...
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Article
Panel discussion on “National laboratory network for immuno-diagnostics of infectious diseases (Nalind)” held on September 6,1997. Brief report
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Article
Evaluation …… neurotuberculosis
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Article
Diagnostic utility of tumor markers in identification of unknown primary?
A 67 years old male patient presented with skeletal metastasis and an unidentified primary neoplasm was referred to department of Biochemistry, NIMS for estimation of tumor markers. High values of CA-19-9, CEA...
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Article
Evaluation of A60 antibodies in pulmonary and neurotuberculosis
Humoral immune response against PPD derived A60 antigen was evaluated by quantification of serum A60 antibodies in thrity healthy adults not exposed to tuberculosis (Group 1), in twenty seven healthy adults ex...
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Article
Superiority of CA 125 over CA 19-9 and CEA for epithelial ovarian malignancies
In this study tumor markers CA 125, CEA and CA 19-9 were evaluated to assess the best tumor marker for epithelial ovarian carcinomas in diagnosis, prognosis and management. The results indicated that CA 125 is...
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Article
A comparative study of tumor markers of adenocarcinoma prostate
The present study deals with the evaluation and comparison of the tumor markers for prostatic carcinoma—The Total Acid Phosphatase (ACP Total) and its Prostatic Fraction (ACP PF) estimated by the enzyme kineti...
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Article
Intracellular proteins as Tumor markers
With the development of new and sensitive techniques for detection of very minute quantities of biomolecules now it is possible to identify the changes in the levels of gene regulatory enzymes and other substa...
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Article
Screening of HLA antibodies in maternal sera from Hyderabad
Antibodies against human leucocyte antigens (HLA) in sera from uni and multiparous women are the potential source of HLA reagent. The present study was undertaken to screen 169 sera from pregnant women for the...
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Article
The dependence of glycosyltransferases inDictyostelium discoideum on the structure of polyisoprenols
Mannosyltransferases in plasma membranes ofDictyostelium discoideum synthesize polyisoprenyl-phosphomannosides from exogenous polyisoprenylphosphates and GDP-mannose. The specificity of the enzymes depends on the...
