33 Result(s)

Article

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Genetic pleiotropy is abundant across spatially distributed brain characteristics derived from one neuroimaging modality (e.g. structural, functional or diffusion magnetic resonance imaging [MRI]). A better un...

E. P. Tissink, A. A. Shadrin, D. van der Meer, N. Parker… in Nature Communications (2024)

Article

The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study

Perioperative goal-directed therapy is considered to improve patient outcomes after high-risk surgery. The association of compliance with perioperative goal-directed therapy protocols and postoperative outcome...

M. F. Boekel, C. S. Venema, T. Kaufmann… in Journal of Clinical Monitoring and Computi… (2021)

Article

The generation of neutrophils in the bone marrow is controlled by autophagy

Autophagy has been demonstrated to have an essential function in several cellular hematopoietic differentiation processes, for example, the differentiation of reticulocytes. To investigate the role of autophag...

S Rožman, S Yousefi, K Oberson, T Kaufmann, C Benarafa… in Cell Death & Differentiation (2015)

Article

Targeting disease by immunomodulation

T Kaufmann, H U Simon in Cell Death & Differentiation (2015)

Article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally ...

L Galluzzi, J M Bravo-San Pedro, I Vitale, S A Aaronson… in Cell Death & Differentiation (2015)

Article

Intracellular localization of the BCL-2 family member BOK and functional implications

The pro-apoptotic BCL-2 family member BOK is widely expressed and resembles the multi-BH domain proteins BAX and BAK based on its amino acid sequence. The genomic region encoding BOK was reported to be frequently...

N Echeverry, D Bachmann, F Ke, A Strasser, H U Simon… in Cell Death & Differentiation (2013)

Article

Consequences of the combined loss of BOK and BAK or BOK and BAX

The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of ...

F Ke, P Bouillet, T Kaufmann, A Strasser, J Kerr, A K Voss in Cell Death & Disease (2013)

Article

Erratum: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

Correction to: Cell Death and Differentiation (2012) 19, 915–925; doi: 10.1038/cdd.2011.210; published online 27 January 2012 Since the publication of this issue, the authors have noticed that the y-axis numbe...

F Ke, A Voss, J B Kerr, L A O'Reilly, L Tai, N Echeverry… in Cell Death & Differentiation (2013)

Article

TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner

Paracetamol (acetaminophen, APAP) is a universally used analgesic and antipyretic agent. Considered safe at therapeutic doses, overdoses cause acute liver damage characterized by centrilobular hepatic necrosis...

A Badmann, S Langsch, A Keogh, T Brunner, T Kaufmann, N Corazza in Cell Death & Disease (2012)

Article

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

BOK/MTD was discovered as a protein that binds to the anti-apoptotic Bcl-2 family member MCL-1 and shares extensive amino-acid sequence similarity to BAX and BAK, which are essential for the effector phase of ...

F Ke, A Voss, J B Kerr, L A O'Reilly, L Tai, N Echeverry… in Cell Death & Differentiation (2012)

Article

Fas death receptor signalling: roles of Bid and XIAP

Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor receptor superfamily that contain an intracellular death domain, can initiate apoptosis signalling and has a critical role ...

T Kaufmann, A Strasser, P J Jost in Cell Death & Differentiation (2012)

Article

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

Acetaminophen (N-acetyl-para-aminophenol (APAP), paracetamol) is a commonly used analgesic and antipyretic agent. Although considered safe at therapeutic doses, accidental or intentional overdose causes acute liv...

A Badmann, A Keough, T Kaufmann, P Bouillet, T Brunner, N Corazza in Cell Death & Disease (2011)

Article

International EMBO workshop on ‘model organisms in cell death research’, Obergurgl (Austria)

K Bianchi, P J Jost, T Kaufmann, R Rutkowski in Cell Death & Differentiation (2009)