8 Result(s)

Article

Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have previously demonstrated that human iPSC-derived astrocytes ingest and modify synthetic tau fibril...

Khalid Eltom, Tobias Mothes, Sylwia Libard… in Acta Neuropathologica Communications (2024)

Article

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be of neuronal origin. However, the...

Tobias Mothes, Benjamin Portal… in Acta Neuropathologica Communications (2023)

Article

Correction to: Complete functional recovery in a child after endovascular treatment of basilar artery occlusion caused by spontaneous dissection: a case report

Ljubisa Borota, Sylwia Libard, Markus Fahlström, Francesco Latini… in Child's Nervous System (2022)

Article

Complete functional recovery in a child after endovascular treatment of basilar artery occlusion caused by spontaneous dissection: a case report

Stroke caused by dissection of arteries of the vertebrobasilar system in children is still poorly investigated in terms of etiology, means of treatment, course of disease, and prognosis. The aim of this report...

Ljubisa Borota, Sylwia Libard, Markus Fahlström, Francesco Latini… in Child's Nervous System (2022)

Article

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated fo...

Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran… in Nature Communications (2021)

Article

Alzheimer’s disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer’s disease

Here, we assessed unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus (iNPH). Our cohort of 95 subjects with age ranging from 75 to 79 years, displayed a hi...

Sylwia Libard, Irina Alafuzoff in Acta Neuropathologica Communications (2019)

Article

Characteristics of the tissue section that influence the staining outcome in immunohistochemistry

Immunohistochemistry (IHC) is influenced by several factors such as cold ischemia time, fixative, fixation time, paraffin, storage time, antibody, antigen retrieval technique and detection systems. In the sett...

Sylwia Libard, Dijana Cerjan, Irina Alafuzoff in Histochemistry and Cell Biology (2019)

Article

Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy

Craniopharyngiomas are histologically benign but locally aggressive tumors in the sellar region that may cause devastating neurological and endocrine deficits. They tend to recur following surgery with high mo...

Elham Rostami, Petra Witt Nyström, Sylwia Libard, Johan Wikström… in Acta Neurochirurgica (2017)