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Open AccessProteomic analysis of the urothelial cancer landscape
Urothelial bladder cancer (UC) has a wide tumor biological spectrum with challenging prognostic stratification and relevant therapy-associated morbidity. Most molecular classifications relate only indirectly t...
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Open AccessProteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors
Lung cancer is the leading cause of cancer-related deaths worldwide with lung adenocarcinoma (LUAD) being the most common type. Genomic studies of LUAD have advanced our understanding of its tumor biology and ...
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Open AccessEpCAM tumor specificity and proteoform patterns in urothelial cancer
The role of the epithelial cell adhesion molecule (EpCAM) in cancer is still unclear. EpCAM cleavage through regulated intramembrane proteolysis results in fragments which interact with both oncogenic and tumo...
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Article
Open AccessTumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
The immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of profound clinical relevance. In this study, we analyzed the cooperati...
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Article
Experimental in vitro, ex vivo and in vivo models in prostate cancer research
Androgen deprivation therapy has a central role in the treatment of advanced prostate cancer, often causing initial tumour remission before increasing independence from signal transduction mechanisms of the an...
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Article
The alternative renin-angiotensin-system (RAS) signalling pathway in prostate cancer and its link to the current COVID-19 pandemic
The renin-angiotensin system is known to maintain blood pressure and body fluids. However, it has been found to consist of at least two major constituents, the classic and the alternative pathway, balancing an...
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Molekulare Mechanismen der Resistenzentstehung und pathologische Aspekte der Therapieplanung beim Prostatakarzinom
Das klinische Management von Patienten mit fortgeschrittenem und metastasiertem Prostatakarzinom wird zunehmend durch die Resistenzentwicklung auf eine antiandrogene Therapie bestimmt. Dementsprechend spielt n...
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Article
Open AccessDNA methylation-based classification of sinonasal tumors
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SN...
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Correction to: Deglycosylation of pathological specimens alters performance of diagnostic PDL1 antibodies
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Deglycosylation of pathological specimens alters performance of diagnostic PDL1 antibodies
Immunohistochemical (IHC) predictive quantitation of PDL1 expression is obligatory in many cancer entities with improved response to immune checkpoint inhibition in PDL1-positive subgroups. With recent demonst...
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Open AccessComprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer
Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes tha...
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Open AccessSystematic evaluation and optimization of protein extraction parameters in diagnostic FFPE specimens
Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for diagnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While n...
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Article
Open AccessNachweis der BRAF-V600E-Mutation beim metastasierten kolorektalen Karzinom
Ringversuche sind ein wichtiges Instrument zur Qualitätssicherung. Dies betrifft in zunehmendem Maße auch die molekulare Diagnostik in der Pathologie, von deren Ergebnissen Therapieentscheidungen in der Präzis...
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Open AccessAggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activati...
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Article
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
The mechanisms behind the evolution of complex genomic amplifications in cancer have remained largely unclear. Using whole-genome sequencing data of the pediatric tumor neuroblastoma, we here identified a type...
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Open AccessParaneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review
Recently, antibodies against the alpha isoform of the glial-fibrillary-acidic-protein (GFAPα) were identified in a small series of patients with encephalomyelitis. Coexisting autoantibodies (NMDA receptor, GAD...
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Article
Cyclin-abhängige Kinasen als Target
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Novel approaches to target the microenvironment of bone metastasis
Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast and prostate cancers, the most common malignancies in women and men, respectively, have a particularly high propensity t...
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Open AccessIdentification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
The only potentially curative treatment for lung adenocarcinoma patients remains complete resection of early-stage tumors. However, many patients develop recurrence and die of their disease despite curative su...
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Histopathologie der Lungentuberkulose
Obwohl die histologischen Charakteristika der Lungentuberkulose seit langem bekannt sind, ist die Diagnose einer nicht mikrobiologisch gesicherten Tuberkulose mit den der Pathologie zur Verfügung stehenden Mit...
