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Open AccessA Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors
Adavosertib (AZD1775) is a first-in-class, selective, small-molecule inhibitor of Wee1.
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Open AccessA phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors
Adavosertib selectively inhibits Wee1, which regulates intra-S and G2/M cell-cycle checkpoints. This study investigated dosing schedules for adavosertib monotherapy, determining the maximum tolerated dose (MTD...
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Intrathymic delivery of plasmid-encoding endoplasmic reticulum signal-sequence-deleted MHC class I alloantigen can induce long-term allograft survival
Intrathymic (IT) delivery of donor alloantigen is a potent strategy to induce operational tolerance. In this study we determined whether this effect was dependent on direct allorecognition of the tolerogen. Te...
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Growth and Neurobehavioral Development of Infant Baboons Exposed Prenatally to Increase Uterine Myometrial Activity
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Development of Circadian Rhythms in Newborn Baboons
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Nurses’ Responsibilities in the Implementation of Information Systems
The influence of nursing on the decision-making process of selecting healthcare information systems (HISs) is increasing. Systems planning and implementation are based not only on the capabilities of informati...
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Chapter
Nurses’ Responsibilities in Implementation of Information Systems
The influence of nursing on the decision-making process of the selection of hospital information systems (HIS) is increasing. Systems planning and implementation are based on not only the capabilities of infor...
