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  1. Article

    Open Access

    Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

    Inotuzumab ozogamicin is an antibody-drug conjugate approved for treating relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in adults. Pediatric pharmacokinetic data of inotuzumab ozo...

    Jen-Hao Wu, Edoardo Pennesi, Francisco Bautista, May Garrett… in Clinical Pharmacokinetics (2024)

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  2. Article

    Open Access

    ECLIM-SEHOP: how to develop a platform to conduct academic trials for childhood cancer

    ECLIM-SEHOP platform was created in 2017. Its main objective is to establish the infrastructure to allow Spanish participation into international academic collaborative clinical trials, observational studies, ...

    Antonio Juan-Ribelles, Francisco Bautista… in Clinical and Translational Oncology (2024)

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  3. No Access

    Article

    Tisagenlecleucel in pediatric and young adult patients with Down syndrome-associated relapsed/refractory acute lymphoblastic leukemia

    Down syndrome-associated acute lymphoblastic leukemia (DS-ALL) patients suffer risk of chemotherapy-associated toxicities and poor outcomes. We evaluated tisagenlecleucel in 16 patients with DS-ALL in two phas...

    Theodore W. Laetsch, Shannon L. Maude, Adriana Balduzzi, Susana Rives… in Leukemia (2022)

  4. Article

    Open Access

    Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial

    Inotuzumab Ozogamicin is a CD22-directed antibody conjugated to calicheamicin, approved in adults with relapsed or refractory (R/R) B cell acute lymphoblastic leukemia (BCP-ALL). Patients aged 1–18 years, with...

    Edoardo Pennesi, Naomi Michels, Erica Brivio, Vincent H. J. van der Velden… in Leukemia (2022)

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  5. No Access

    Article

    Outcomes for paediatric acute leukaemia patients admitted to the paediatric intensive care unit

    Children with acute leukaemia (AL) are a high-risk population for infections and life-threatening conditions requiring paediatric intensive care unit (PICU) admission, presenting an increased mortality rate. A...

    Marina Caballero, Anna Faura, Adriana Margarit… in European Journal of Pediatrics (2022)

  6. No Access

    Article

    Influence of new antiretrovirals on hematological toxicity in HIV-exposed uninfected infants

    Maternal combined antiretroviral therapy (cART) successfully prevents HIV mother-to-child transmission but also causes hematological toxicity in the HIV-exposed uninfected (HEU) infant. We performed a single-c...

    Núria Rovira, Antoni Noguera-Julian, Susana Rives… in European Journal of Pediatrics (2016)