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Article
Open AccessImmunogenicity and efficacy of pembrolizumab and doxorubicin in a phase I trial for patients with metastatic triple-negative breast cancer
Currently there is a limited understanding for the optimal combination of immune checkpoint inhibitor and chemotherapy for patients with metastatic triple-negative breast cancer (mTNBC). Here we evaluate the s...
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Article
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth
Epidemiological studies demonstrate an association between breast cancer (BC) and systemic dysregulation of glucose metabolism. However, how BC influences glucose homeostasis remains unknown. We show that BC-d...
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Article
Open AccessSpatial distribution of B cells and lymphocyte clusters as a predictor of triple-negative breast cancer outcome
While tumor infiltration by CD8+ T cells is now widely accepted to predict outcomes, the clinical significance of intratumoral B cells is less clear. We hypothesized that spatial distribution rather than density ...
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Article
Open AccessPhase I clinical trial of the combination of eribulin and everolimus in patients with metastatic triple-negative breast cancer
Alteration of the PI3K/AKT/mTOR pathway is a common genomic abnormality detected in triple-negative breast cancer (TNBC). Everolimus acts synergistically with eribulin in TNBC cell lines and xenograft models. ...
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Article
Open AccessPathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypes
Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...
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Article
Open AccessCombination therapy with BYL719 and LEE011 is synergistic and causes a greater suppression of p-S6 in triple negative breast cancer
A third of patients with triple negative breast cancer (TNBC) have relapsed disease within 2–5 years from initial diagnosis, leaving an unmet need for therapeutic targets. TNBC frequently harbors alterations o...
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Article
Open AccessCCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer
Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological hete...
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Article
The effect of shade on petiole length in the viola fimbriatula-sagittata complex (Violaceae)
In many taxonomic treatments, Viola fimbriatula is distinguished from V. sagittata by the length of the petiole. Field experiments, using both cloned plants and plants grown from seed, demonstrated considerable p...
