Skip to main content

5 Result(s)

within Suraj J. Patel Remove this filter

and

  1. Article

    Open Access

    AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin’s acute effects

    AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. Identifying the relevant transcr...

    Frankie D. Heyward, Nan Liu, Christopher Jacobs… in Nature Communications (2024)

    Download PDF (5514 KB) View Article

  2. No Access

    Article

    Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn’s Disease Is Not Associated with Emergence of Novel Inflammatory Pathways

    While monoclonal antibodies against tumor necrosis factor-α (TNFα) are effective in treating Crohn’s disease (CD), approximately one-third of patients lose response. The mechanisms underlying this loss of resp...

    Jay Luther, Manish Gala, Suraj J. Patel, Maneesh Dave… in Digestive Diseases and Sciences (2018)

  3. No Access

    Article

    Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells

    Tissue-protective properties of erythropoietin (EPO) have let to the discovery of an alternative EPO signaling via an EPO-R/CD131 receptor complex which can now be specifically targeted through pharmaceuticall...

    Stefan Bohr, Suraj J. Patel, Radovan Vasko, Keyue Shen… in Journal of Molecular Medicine (2015)

  4. Article

    Erratum: Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure

    Nat. Biotechnol. 30, 179–183 (2012); doi:10.1038/nbt.2089; published online 15 January 2012; corrected after print 5 December 2013 In the version of this article initially published, Arvin Iracheta-Vellve's na...

    Suraj J Patel, Jack M Milwid, Kevin R King, Stefan Bohr… in Nature Biotechnology (2014)

    Download PDF (104 KB) View Article

  5. No Access

    Article

    Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure

    Liver toxicity is one of the most common reasons for abandoning new drugs in development or withdrawing approved drugs from the market. Patel et al. show that in mice drug-induced liver injury can be limited by s...

    Suraj J Patel, Jack M Milwid, Kevin R King, Stefan Bohr… in Nature Biotechnology (2012)