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Article

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key molecule that causes major neurotoxicity during the early stage of Alzheimer’s disease ...

Jonghee Han, Sunmin Jung, Jiyeon Jang, Tae-In Kam… in Cellular and Molecular Life Sciences (2014)