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Article
Open AccessCyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway
Spatial learning and memory flexibility are known to require long-term potentiation (LTP) and long-term depression (LTD), respectively, on a cellular basis. We previously showed that cyclin Y (CCNY), a synapse...
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Article
Open AccessPhosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress
CAV1/Caveolin1, an integral membrane protein, is involved in caveolae function and cellular signaling pathways. Here, we report that CAV1 is a positive regulator of autophagy under oxidative stress and cerebra...
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Article
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key molecule that causes major neurotoxicity during the early stage of Alzheimer’s disease ...
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Article
Open AccessOverexpression of Atg5 in mice activates autophagy and extends lifespan
Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autoph...
