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  1. Article

    Open Access

    Evaluation of penalized and machine learning methods for asthma disease prediction in the Korean Genome and Epidemiology Study (KoGES)

    Genome-wide association studies have successfully identified genetic variants associated with human disease. Various statistical approaches based on penalized and machine learning methods have recently been pr...

    Yongjun Choi, Junho Cha, Sungkyoung Choi in BMC Bioinformatics (2024)

  2. Article

    Open Access

    Drug response prediction model using a hierarchical structural component modeling method

    Component-based structural equation modeling methods are now widely used in science, business, education, and other fields. This method uses unobservable variables, i.e., “latent” variables, and structural equ...

    Sungtae Kim, Sungkyoung Choi, Jung-Hwan Yoon, Youngsoo Kim in BMC Bioinformatics (2018)

  3. Article

    Open Access

    Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes

    As one possible solution to the “missing heritability” problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology...

    Sungyoung Lee, Yongkang Kim, Sungkyoung Choi, Heungsun Hwang in BMC Bioinformatics (2018)

  4. Article

    Open Access

    Hierarchical structural component modeling of microRNA-mRNA integration analysis

    Identification of multi-markers is one of the most challenging issues in personalized medicine era. Nowadays, many different types of omics data are generated from the same subject. Although many methods endea...

    Yongkang Kim, Sungyoung Lee, Sungkyoung Choi, **-Young Jang in BMC Bioinformatics (2018)