17 Result(s)
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Sungho Won
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters
In this study, we investigated the characteristics of gut microbiome in the metabolically healthy obese (MHO) patients, and how they correlate with metabolic and inflammatory profiles. A total of 120 obese peo...
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Article
Open AccessComparative analysis of batch correction methods for FDG PET/CT using metabolic radiogenomic data of lung cancer patients
In radiomics research, the issue of different instruments being used is significant. In this study, we compared three correction methods to reduce the batch effects in radiogenomic data from fluorodeoxyglucose...
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Article
Open AccessPrenatal phthalate exposure and cord blood DNA methylation
Exposure to phthalates has been shown to impede the human endocrine system, resulting in deleterious effects on pregnant women and their children. Phthalates modify DNA methylation patterns in infant cord bloo...
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Open AccessA genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors...
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Article
Open AccessRisk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study
Intrinsic immunologic disparity of psoriasis itself, along with chronic inflammation and immunomodulatory anti-psoriatic treatments could be associated with increased risk of malignancy. We aimed to estimate t...
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Article
Open AccessUnveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts
Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate t...
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Open AccessCharacterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymo...
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Open AccessIdentification of genetic loci affecting body mass index through interaction with multiple environmental factors using structured linear mixed model
Multiple environmental factors could interact with a single genetic factor to affect disease phenotypes. We used Struct-LMM to identify genetic variants that interacted with environmental factors related to bo...
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Open AccessThe nationwide retrospective cohort study by Health Insurance Review and Assessment Service proves that asthma management decreases the exacerbation risk of asthma
Medical costs have recently increased in South Korea due to the rising rate of asthma. Primary clinics serve an important role in asthma management, as they are the first stop for patients presenting with symp...
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Article
Open AccessEffect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions are expected to affect COPD onset. We ...
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Article
Open AccessAuthor Correction: Type-2 Diabetics Reduces Spatial Variation of Microbiome Based on Extracellular Vesicles from Gut Microbes across Human Body
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessType-2 Diabetics Reduces Spatial Variation of Microbiome Based on Extracellular Vesicles from Gut Microbes across Human Body
As a result of advances in sequencing technology, the role of gut microbiota in the mechanism of type-2 diabetes mellitus (T2DM) has been revealed. Studies showing wide distribution of microbiome throughout th...
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Open AccessLongitudinal decline in lung function: a community-based cohort study in Korea
Progressive decline in lung function is the hallmark of chronic obstructive pulmonary disease (COPD). We aimed to assess the rate of decline in forced expiratory volume in 1 second (FEV1) in patients from a commu...
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Article
Open AccessGenome-wide assessment of gene-by-smoking interactions in COPD
Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions hav...
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Article
Open AccessBiphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma
Protein tyrosine kinase 7 (PTK7), also known as colon carcinoma kinase 4 (CCK-4), is a member of the catalytically defective receptor protein tyrosine kinase family and is upregulated in various cancers, where...
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Article
Open AccessCorrection: Corrigendum: Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study
Scientific Reports 5: Article number: 18422; published online: 21 December 2015; updated: 27 May 2016 This Article contains typographical errors in Table 6. In the column ‘OR (95% CI) by IV estimation’, the Ca...
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Article
Open AccessAlcohol intake and cardiovascular risk factors: A Mendelian randomisation study
Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence of associations of genetic vari...
