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Article
Open AccessGNUV201, a novel human/mouse cross-reactive and low pH-selective anti-PD-1 monoclonal antibody for cancer immunotherapy
Several PD-1 antibodies approved as anti-cancer therapies work by blocking the interaction of PD-1 with its ligand PD-L1, thus restoring anti-cancer T cell activities. These PD-1 antibodies lack inter-species ...
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Article
Open AccessTrametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult...
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Article
Open AccessMEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the patholo...
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Article
Open AccessStructure and dynamics in the lithium solvation shell of nonaqueous electrolytes
The solvation of a lithium ion has been of great importance to understand the structure and dynamics of electrolytes. In mixed electrolytes of cyclic and linear carbonates, the lithium solvation structure and ...
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Article
Open AccessDynamic features of water molecules in superconcentrated aqueous electrolytes
An existence of ions dissolved in water has significant effects on bulk properties of water. Superconcentrated conditions have been recently proposed to provide a new concept of lithium ion batteries in order ...
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Article
Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures
Growing recognition of persistent cognitive defects associated with electroconvulsive therapy (ECT), a highly effective and commonly used antidepressant treatment, has spurred interest in identifying its mecha...
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Article
Open AccessA salient effect of density on the dynamics of nonaqueous electrolytes
The mobility and solvation of lithium ions in electrolytes are crucial for the performance and safety of lithium ion batteries. It has been known that a single type of solvent cannot satisfy the requirements o...
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Article
Phase transitions in confined water nanofilms
Phase transitions in water are normally classified as first or second order. But in confined quasi-one-dimensional films of water, simulations show that the solid–liquid transition can take place by means of a...
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Chapter and Conference Paper
Research of Ride Comfort for Tilting Train Simulator Using ECG
The train transportation has a lot of advantages-energy efficiency is high, it is eco-friendly, safety is better than normal roads and it is possible for people to arrive on time. In these days, the valuation ...
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Chapter and Conference Paper
Ride Comfort Analysis using Physiological Parameters for e-Health Train
When passengers ride in a car of a train, they feel the vibration, which partially defines their degree of comfort. The ISO standards based on existing passenger trains, the Wz evaluation method, UIC standards...
