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    Article

    Cholesterol is obligatory for polarization and chemotaxis but not for endocytosis and associated signaling from chemoattractant receptors in human neutrophils

    Plasma membrane cholesterol is critical for neutrophil chemotaxis, although how cholesterol affects chemotactic signaling pathway has not been clearly delineated. Here we demonstrate that cholesterol was absol...

    Jeremy J. Rose, John F. Foley, Ling Yi, Gina Herren… in Journal of Biomedical Science (2008)

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    Article

    Effects of HIV-1 nef on cellular gene expression profiles

    The early human immunodeficiency virus (HIV) accessory protein Nef makes an important contribution to virulence, but the mechanisms by which Nef influences pathogenesis remain unclear. Many well-studied effect...

    Syed Shaheduzzaman, Vyjayanthi Krishnan, Ana Petrovic… in Journal of Biomedical Science (2002)

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    Article

    Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

    Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target cells by forming a complex between the viral envelope protein and two cell-surface membrane receptors: CD4 and a 7-span t...

    Drew Weissman, Ronald L. Rabin, James Arthos, Andrea Rubbert, Mark Dybul… in Nature (1997)

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    Chapter

    Molecular Functional Studies of HIV-1 REV and NEF Proteins

    Human immunodeficiency virus type 1 (HIV-1), the etiological agent of AIDS, preferentially infects the CD4+ helper subset of human T lymphocytes. Clinically, HIV-1 infection is characterized by a chronic phase...

    Sundararajan Venkatesan, Steven M. Holland… in Advances in Molecular Biology and Targeted… (1991)