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Article
Endometrial Determinism of Endometriosis: An Unnecessary Adjunct to Retrograde Menstruation
The observation that retrograde menstruation is almost universal while only a small proportion of women suffer with endometriosis is among the most quoted challenges to Sampson’s hypothesis. Addressing this ch...
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Article
Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis
Cellular senescence is known to be involved in tissue repair, but its role in adenomyosis remains unclear. This study was tasked to evaluate the expression of Klotho, a well-known aging-suppressing protein, as...
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Article
Open AccessIs neonatal uterine bleeding responsible for early-onset endometriosis?
It has been hypothesized that the origin of early-onset endometriosis could be from endometrial mesenchymal stem cells (eMSCs) in neonatal uterine blood (NUB). There is no information on the possible mechanist...
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Article
Open AccessAssociation between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic
A potential concern has been raised regarding fertility and reproductive outcome during the Covid-19 pandemic with growing stress and anxiety. However, information on the association between tissue stress reac...
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Article
Decreased Glycolysis at Menstruation is Associated with Increased Menstrual Blood Loss
Heavy menstrual bleeding (HMB) is common and severely affects the quality of life of the afflicted women. While HMB is known to be caused by impaired endometrial repair after menstruation, its more proximate c...
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Article
Open AccessActivation of α7 nicotinic acetylcholine receptor retards the development of endometriosis
Women with endometriosis have been shown to have a reduced vagal tone as compared with controls and vagotomy promoted while vagus nerve stimulation (VNS) decelerated the progression of endometriosis in mice. E...
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Article
Open AccessTetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis
The development of more efficacious, non-hormonal therapeutics for endometriosis is still an unmet medical need begging to be fulfilled. Growing evidence indicates that endometriotic lesions are wounds undergo...
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Pathogenesis of Endometriosis: Role of Platelets in Endometriosis
Endometriosis is often likened to cancer, since endometriotic lesions also exhibit proliferation, apoptosis resistance, invasion, inflammation, angiogenesis, epigenetic aberration, and even cancer-driver mutat...
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Article
Open AccessPossible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis
Accumulating data indicate that sensory nerve derived neuropeptides such as substance P and calcitonin gene related-protein (CGRP) can accelerate the progression of endometriosis via their respective receptors...
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Article
Open AccessReduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach
Sensory and sympathetic nerves have been shown to promote the progression of endometriosis through the release of neuromediators and the lesional activation of respective receptors. The role of vagus nerves (V...
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Article
Enriched Environment Decelerates the Development of Endometriosis in Mouse
We tested the hypothesis that enriched environment (EE), consisting of enlarged space, and increased physical activity and social interactions, hinders the development of endometriosis through attenuated adren...
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Article
Diagnosing Deep Endometriosis Using Transvaginal Elastosonography
Transvaginal ultrasound (TVUS) and MRI are currently two mainstream imaging techniques used to diagnose deep endometriosis (DE) with comparable accuracy, but there is still ample room for improvement. As endom...
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Article
Open AccessEarly maternal separation accelerates the progression of endometriosis in adult mice
A large body of research highlights the importance of early-life environmental impact on the health outcome in adulthood. However, whether early-life adversity (ELA) has any impact on the development of endome...
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Article
Open AccessAuthor Correction: Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessPlatelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells
Endometriosis is estrogen-dependent disorder. Two theories provide the explanations for the increased estrogen production. One is the feed-forward loop model linking inflammation and estrogen production. The m...
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Article
Scutellarin Suppresses Platelet Aggregation and Stalls Lesional Progression in Mouse With Induced Endometriosis
Platelets play an important role in the development of endometriosis. Scutellarin is a flavonoid isolated from a medicinal herb traditionally used as a potent antiplatelet agent. In this study, we sought to ev...
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Article
Open AccessPlasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis
Identification of biomarkers for endometriosis is an unmet medical need that demands to be fulfilled. In this study, we first used a mouse model of endometriosis and evaluated the potential utility of select b...
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Article
Genesis, genes and epigenetics of endometriosis-associated infertility
Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberran...
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Article
Open AccessNeuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis
Endometriotic lesions are known to be hyperinnervated, especially in lesions of deep endometriosis (DE), which are frequently in close proximity to various nerve plexuses. DE lesions typically have higher fibr...
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Article
Open AccessEnhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis
EZH2, a subunit of the polycomb repressive complex 2 (PRC2) catalyzing trimethylation of histone H3 lysine 27 (H3K27), induces epithelial-mesenchymal transition (EMT) in cancers. However, whether EZH2 regulate...
