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Article
Open AccessRFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Proneural genes play a crucial role in neuronal differentiation. However, our understanding of the regulatory mechanisms governing proneural genes during neuronal differentiation remains limited. RFX4, identif...
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Article
Open AccessDMRT1 regulates human germline commitment
Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epigenetic programme and competence for gametogenesis. Here we follow the progression of nas...
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Article
Open AccessComparison of automated quantification of amyloid deposition between PMOD and Heuron
Several programs are widely used for clinical and research purposes to automatically quantify the degree of amyloid deposition in the brain using positron emission tomography (PET) images. Given that very few ...
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Metronidazole
Metronidazole is one of the major antibiotics for the eradication of Helicobacter pylori (H. pylori). The metronidazole resistance rate of H. pylori is relatively high compared to other antibiotics. It appears to...
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Article
Open AccessImpact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study
In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based mul...
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Article
Open AccessAglycosylated antibody-producing mice for aglycosylated antibody-lectin coupled immunoassay for the quantification of tumor markers (ALIQUAT)
Targeting aberrant glycoforms has been validated for in vitro cancer diagnostic development, and several assays are currently in routine clinical use. Because N-glycans in Fc region of antibodies show cross-re...
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Article
Open AccessNon-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation
Although astrocytes have gained increased recognition as an important regulator in normal brain function and pathology, the mechanisms underlying their genesis are not well understood. In this study, we show t...
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Article
Open AccessPrevalence, incidence, and mortality of nontuberculous mycobacterial infection in Korea: a nationwide population-based study
Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large ...
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Article
Open AccessGut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats
The association between adverse effects of PPI and gut microbiota in old age has yet to be elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PP...
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Article
Open AccessPrevalence and risk factors of latent tuberculosis among Korean healthcare workers using whole-blood interferon-γ release assay
Because healthcare workers (HCWs) are at high risk for tuberculosis (TB) infection, it is essential to research the prevalence of latent TB infection (LTBI) and to implement health interventions including earl...
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Steroid-induced hyperglycemic chorea in a patient without diabetes mellitus
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Open AccessChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining
Various chromatin modifications, identified in large-scale epigenomic analyses, are associated with distinct phenotypes of different cells and disease phases. To improve our understanding of these variations, ...
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Article
Reversible chorea and parkinsonism in a patient with systemic lupus erythematosus
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Article
Genome-wide profiling of in vivo LPS-responsive genes in splenic myeloid cells
Lipopolysaccharide (LPS), the major causative agent of bacterial sepsis, has been used by many laboratories in genome-wide expression profiling of the LPS response. However, these studies have predominantly used
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Article
Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients
In response to the pandemic 2009 A/H1N1 virus, monovalent MF59-adjuvanted vaccines were prepared. Recently, single 3.75-μg doses of MF59-adjuvanted vaccines have shown good immunogenicity in young adults. Howe...
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Article
Clinical features of severe acquired ADAMTS13 deficiency in thrombotic thrombocytopenic purpura: the Korean TTP registry experience
The clinical significance of ADAMTS13 activity for response to treatment, mortality rate, recurrence, and prognosis is unclear. Therefore, we investigated the characteristics of severe ADAMTS13 deficiency and ...
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Article
Demonstration of striatopallidal iron deposition in chorea-acanthocytosis by susceptibility-weighted imaging
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Article
Open AccessMulticenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma
Several single center studies have provided evidence of immune activation and antitumor activity of therapeutic vaccination with dendritic cells (DC) in patients with metastatic melanoma. The efficacy of this ...
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Article
DECREASED INTERLEUKIN-15 (IL-15) mRNA EXPRESSION FROM ACTIVATED CORD (C) VS. ADULT (A) PERIPHERAL BLOOD (PB) MONONUCLEAR CELLS (MNC): IMPLICATION IN THE IMMATURITY OF NEONATAL IMMUNE FUNCTION AND DECREASED GRAFT-V
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Article
MOLECULAR ANALYSIS OF DECREASED GM-CSF mRNA STABILITY IN NEONATAL VS. ADULT MONONUCLEAR CELLS: ASSOCIATION WITH INCREASED LEVELS OF SPECIFIC AUUUA-BINDING AUF1 PROTEINS AND INCREASED IN VITRO DEGRADATION.
