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Article
Medicinal Rhodiola imbricata induces protective immune responses against susceptible and resistant strains of Leishmania donovani in murine model
Visceral leishmaniasis (VL) is an infectious disease caused by protozoa, Leishmania. During infection, the cell-mediated immunity of host gets impeded, so immunomodulation using natural products can be considered...
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Article
Review Article on Molecular Mechanism of Regulation of Hypertension by Macro-elements (Na, K, Ca and Mg), Micro-elements/Trace Metals (Zn and Cu) and Toxic Elements (Pb and As)
Hypertension (HT) is a medical condition arising due to increase in blood pressure (BP) prevalent worldwide. The balanced dietary intakes of macro-elements and micro-elements including Na, K, Ca, Mg, Zn, and C...
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Article
Open AccessWhy do humans need thrombospondin-1?
Matricellular proteins comprise several families of secreted proteins that function in higher animals at the interface between cells and their surrounding extracellular matrix. Targeted gene disruptions that r...
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Article
In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model
Parasite of genus Leishmania viz. L. donovani and L. infantum cause visceral leishmaniasis (VL) or Kala-azar, systemic disease with significant enlargement of the liver and spleen, weight loss, anemia, fever and ...
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Article
Heavy metals controlling cardiovascular diseases risk factors in myocardial infarction patients in critically environmentally heavy metal-polluted steel industrial town Mandi-Gobindgarh (India)
Heavy metals (HMs) have a very significant clinical role in the pathogenesis, progression and management of cardiovascular diseases (CVDs). The prevalence of CVDs was reported to be higher in critically enviro...
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Article
Open AccessCD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a component of extracellular vesicles (EVs) released by various cell types. Previous studies identified CD47-dependent functi...
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Article
Laboratory evaluation of performance of pulse oximeters from six different manufacturers during motion artifacts produced by Fluke 2XL SpO2 simulator
We performed laboratory evaluation of six pulse oximeters from different manufacturers using the Fluke 2XL SpO2 simulator. The pulse oximeter probes were labeled 1 through 6 and tested using the two pre-programed...
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Article
Correction to: Obituary
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Article
GC–MS screening and antiparasitic action of Putranjiva roxburghii leaves against sensitive and resistant strains of Leishmania donovani
Looming drug resistance cases of leishmaniasis infection are an undeniably serious danger to worldwide public health, also jeopardize the efficacy of available drugs. Besides this, no successful vaccine is ava...
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Article
Antiparasitic potential of Indian honey bee glue against strains of Leishmania donovani sensitive and resistant to synthetic antileishmanial
Honey bee glue (HBG) or propolis is produced by honey bees and used as cementing material for sealing within the hive which is considered as a waste by the beekeepers. Due to its umpteen biological properties,...
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Article
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the dru...
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Article
Evaluation of In vitro and In vivo Protective Efficacy of Bauhinia variegata Against Leishmania donovani in Murine Model
Visceral leishmaniasis is one of the ignored parasitic infection affecting millions of people globally. Currently, available treatment options are unsatisfactory because of high cost and side effects of the le...
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Article
Differential intolerance to loss of function and missense mutations in genes that encode human matricellular proteins
Targeted gene disruption in mice has provided valuable insights into the functions of matricellular proteins. Apart from missense and loss of function mutations that have been associated with inherited disease...
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Article
Health concerns on provisional tolerable weekly intake of aluminium in children and adults from vegetables in Mandi-Gobindgarh (India)
Metallurgical industrial processes have been reported to cause higher aluminium (Al) exposure in humans through plant food intake due to higher soil Al content and acidification of soil resulted from industria...
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Article
Recent apprise on coronavirus and its terrible insinuations
Epidemically increased evidence reveals that the link between the 2019-nCoV and other similar strain of coronaviruses circulating in bats and specifically the Rhinopodous bat sub-species. These sub-species are...
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Article
Leishmaniasis diagnosis: an update on the use of parasitological, immunological and molecular methods
Diagnosis of leishmaniasis has always been a major challenge as its clinical features resemble some other commonly occurring diseases such as tuberculosis, typhoid, and malaria. Reliable laboratory methods bec...
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Article
Understanding the problems in pharmaceutical procurement with special reference to active pharmaceutical ingredients and excipients
Procurement of raw materials, key intermediates and excipients for the preparation of finished pharmaceutical preparation is considered to be complex process which involve multiple channels and require skilled...
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Article
A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells
Tumor cells release extracellular vesicles (EVs) into the tumor microenvironment that may facilitate malignant progression and metastasis. Breast carcinoma EVs express high levels of the thrombospondin-1 and s...
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Article
Open AccessCD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs
Extracellular vesicles (EVs) mediate the intercellular transfer of RNAs, which alter gene expression in target cells. EV heterogeneity has limited progress towards defining their physiological functions and ut...
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Reference Work Entry In depth
Thrombospondin-1