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  1. Article

    Open Access

    The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

    Accurate DNA replication is essential for genomic stability and cancer prevention. Homologous recombination is important for high-fidelity DNA damage tolerance during replication. How the homologous recombinat...

    Joel C. Rosenbaum, Braulio Bonilla, Sarah R. Hengel, Tony M. Mertz… in Nature Communications (2019)

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    The Diverse Active Sites in Splicing, Debranching, and MicroRNA Processing Around RNA Phosphodiester Bonds

    The cleavage and ligation reactions at RNA phosphodiester bonds are the central reactions catalyzed by enzymes in critical cellular regulatory pathways. In pre-mRNA splicing, two phospho-transesterifications r...

    Sourav Kumar Dey, Eduardo Paredes… in From Nucleic Acids Sequences to Molecular … (2012)

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    Article

    General acid catalysis by the hepatitis delta virus ribozyme

    Recent crystallographic and functional analyses of RNA enzymes have raised the possibility that the purine and pyrimidine nucleobases may function as general acid-base catalysts. However, this mode of nucleoba...

    Subha R Das, Joseph A Piccirilli in Nature Chemical Biology (2005)