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Article
Open AccessTektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella
Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is pr...
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Article
Testicular germ cell tumor: a comprehensive review
Testicular tumors are the most common tumors in adolescent and young men and germ cell tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs among males provides strong motiv...
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Article
Open AccessCRISPR/Cas9-mediated genome editing induces gene knockdown by altering the pre-mRNA splicing in mice
Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9 (CRISPR/Cas9) has been wildly used to generate gene knockout models through inducing indels causing frame-shift. However, t...
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Article
Open AccessA miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth
Tumor growth is modulated by crosstalk between cancer cells and the tumor microenvironment. Recent advances have shown that miRNA dysfunction in tumor cells can modulate the tumor microenvironment to indirectl...
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Article
Role of WNT signaling in epididymal sperm maturation
Spermatozoa maturation, a process required for spermatozoa to acquire progressive motility and the ability to fertilize ova, primarily occurs in the caput and corpus of the epididymis. Despite considerable eff...
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Article
Open AccessRequirement for CCNB1 in mouse spermatogenesis
Spermatogenesis, which involves mitosis and meiosis of male germ cells, is a highly complicated and coordinately ordered process. Cyclin B1 (CCNB1), an important regulator in cell cycle machinery, is proved es...
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Article
Open AccessThe control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon’s head to tail
Male infertility due to abnormal spermatozoa has been reported in both animals and humans, but its pathogenic causes, including genetic abnormalities, remain largely unknown. On the other hand, contraceptive o...
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Article
Open AccessDoes murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models
Wingless-related MMTV integration site (WNT) proteins and several other components of the WNT signalling pathway are expressed in the murine testes. However, mice mutant for WNT signalling effector β-catenin usin...
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Article
Open AccessSodium–hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility
Our previous work identified NHA1, a testis-specific sodium–hydrogen exchanger, is specifically localized on the principal piece of mouse sperm flagellum. Our subsequent study suggested that the number of newb...
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Article
Open AccessDisruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration
The directional migration and the following development of primordial germ cells (PGCs) during gonad formation are key steps for germline development. It has been proposed that the interaction between germ cel...
