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Article
Open AccessIP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...
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Article
Open AccessHigh glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy
Mitochondrial dysfunction and impaired Ca2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of ph...
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Article
Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats
Hypertension is one of the risk factors for coronary heart disease. The present study investigated the mechanism of contractile dysfunction induced by serotonin (5-HT) in coronary artery in spontaneously hyper...
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Article
Atorvastatin ameliorates the contractile dysfunction of the aorta induced by organ culture
Statins are widely used in the treatment of hypercholesterolemia. Studies have demonstrated that statins could maintain vascular contractile function through inhibiting the transformation of vascular smooth mu...
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Article
Open AccessLeft ventricular deformation associated with cardiomyocyte Ca2+ transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats
In the early stage of diabetes, the cardiac ejection fraction is preserved, despite the existence of the subclinical cardiac dysfunction to some extent. However, the detailed phenotype of this dysfunction and ...
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Article
Species-specific differences in the role of L-type Ca2+ channels in the regulation of coronary arterial smooth muscle contraction
The L-type calcium channel (LCC) plays a regulatory role in various physical and pathological processes. In the vasculature, LCCs mediate agonist-induced vascular smooth muscle contraction. However, whether LC...
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Article
Open AccessInhibition of LDHA suppresses tumor progression in prostate cancer
A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tum...
