49 Result(s)

Article

Epigenetic signature of very low birth weight in young adult life

Globally, one in ten babies is born preterm (<37 weeks), and 1–2% preterm at very low birth weight (VLBW, <1500 g). As adults, they are at increased risk for a plethora of health conditions, e.g., cardiometabo...

Juho Kuula, Darina Czamara, Helena Hauta-alus, Jari Lahti… in Pediatric Research (2024)

Article

Low-grade inflammation from prenatal period to age 6–8 years in a Vitamin D trial

Low-grade systemic inflammation measured as high sensitivity C-reactive protein (hs-CRP) has been associated with non-communicable disease risk. We assessed whether prenatal inflammation and early-childhood vi...

Helena H. Hauta-alus, Jenni Rosendahl, Elisa M. Holmlund-Suila… in Pediatric Research (2024)

Article

Body composition in adults born preterm with very low birth weight

Studies on body composition in preterm very low birth weight (VLBW < 1500 g) survivors are inconsistent and trajectories later in life unknown. We assessed body composition and its change from young to mid-adu...

Laura Jussinniemi, Maarit K. Kulmala, Kristina A. D. Aakvik… in Pediatric Research (2024)

Article

Correction to: Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants

Maija Seppä-Moilanen, Sture Andersson, Turkka Kirjavainen in Pediatric Research (2022)

Article

Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants

Caffeine is widely used in preterm infants for apnea control. It has no effect on sleep in the only existing polysomnographic study including ten preterm infants Behavioral and polygraphic studies have conflic...

Maija Seppä-Moilanen, Sture Andersson, Turkka Kirjavainen in Pediatric Research (2022)

Article

Early oxygen levels contribute to brain injury in extremely preterm infants

Extremely low gestational age newborns (ELGANs) are at risk of neurodevelopmental impairments that may originate in early NICU care. We hypothesized that early oxygen saturations (SpO₂), arterial pO₂ levels, and ...

Krista Rantakari, Olli-Pekka Rinta-Koski, Marjo Metsäranta… in Pediatric Research (2021)

Article

Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants

Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediat...

Liina Süvari, Otto M. Helve, M. Anneli Kari, L. Ursula Turpeinen… in Pediatric Research (2021)

Article

25-hydroxyvitamin D correlates with inflammatory markers in cord blood of healthy newborns

Vitamin D is a potent immunomodulator and may play a role in the development of the fetal innate immune functions. The aim of our study was to evaluate inflammatory markers in cord blood of healthy newborns in...

Jenni Rosendahl, Elisa Holmlund-Suila, Otto Helve, Heli Viljakainen… in Pediatric Research (2017)

Article

Growth after late-preterm birth and adult cognitive, academic, and mental health outcomes

Late-preterm birth (at 34^0⁄7–36^6⁄7 wk gestation) increases the risk of early growth faltering, poorer neurocognitive functioning, and lower socio-economic attainment. Among early-preterm individuals, faster early...

Sara Sammallahti, Kati Heinonen, Sture Andersson, Marius Lahti… in Pediatric Research (2017)

Article

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

Higher cortical function during sensory processing can be examined by recording specific somatosensory-evoked magnetic fields (SEFs) with magnetoencephalography (MEG). We evaluated whether, in extremely low-ge...

Petri Rahkonen, Päivi Nevalainen, Leena Lauronen, Elina Pihko… in Pediatric Research (2013)

Article

Low monocyte HLA-DR expression as an indicator of immunodepression in very low birth weight infants

As a protective response to an inflammatory stimulus, the antigen-presenting molecules (human leukocyte antigen-DR (HLA-DR)) on monocytes are downregulated. If severe, the response may lead to immunodepression...

Anniina Palojärvi, Jari Petäjä, Sanna Siitonen, Cecilia Janér… in Pediatric Research (2013)

Article

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

This study was set out to develop and describe a novel, simple, and safe method for routine bedside testing of somatosensory system in very early preterm infants. We recorded electroencephalogram (EEG) activit...

Sampsa Vanhatalo, Veikko Jousmäki, Sture Andersson, Marjo Metsäranta in Pediatric Research (2009)

Article

Altered Cardiovascular Control in Preterm Infants with Bronchopulmonary Dysplasia

Vestibulo-mediated cardiovascular control in hazardous situations is important. Our hypothesis is that the prerequisite for sudden infant death syndrome (SIDS) is impaired vestibulo-mediated cardiovascular con...

Suvi Viskari, Sture Andersson, Timo Hytinantti, Turkka Kirjavainen in Pediatric Research (2007)

Article

Up-Regulation of Trypsin and Mesenchymal MMP-8 During Development of Hyperoxic Lung Injury in the Rat

Acute lung injury is marked by damage to alveolar-capillary barrier. High pulmonary levels of matrix-degrading serine proteinase trypsin and matrix metalloproteinases (MMP)-2, -8, and -9 have been shown in pre...

Katariina Cederqvist, Joakim Janer, Taina Tervahartiala, Timo Sorsa… in Pediatric Research (2006)

Article

Placental 11β-HSD2 Activity, Early Postnatal Clinical Course, and Adrenal Function in Extremely Low Birth Weight Infants

The placental enzyme 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) transforms maternal cortisol to inactive cortisone. Fetal glucocorticoid excess due to reduced 11β-HSD2 activity could make small preterm infa...

Eero Kajantie, Leo Dunkel, Ursula Turpeinen, Ulf-Håkan Stenman… in Pediatric Research (2006)

Article

High Expression of Pulmonary Proteinase-activated Receptor 2 in Acute and Chronic Lung Injury in Preterm Infants

Proteinase-activated receptor 2 (PAR₂), a G-protein-coupled receptor activated by serine proteinases such as trypsin, has been suggested to play an important role in inflammatory and fibroproliferative processes....

Katariina Cederqvist, Caj Haglund, Päivi Heikkilä… in Pediatric Research (2005)

Article

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Late-onset hospital-acquired sepsis is common in extremely low birth-weight (<1000g) (ELBW) infants. The diagnosis is difficult since, at early stages of sepsis, routine laboratory tests are neither specific n...

Riikka Turunen, Sture Andersson, Irmeli Nupponen, Hannu Kautiainen… in Pediatric Research (2005)

Article

Extracellular Release of Bactericidal/Permeability-Increasing Protein in Newborn Infants

Upon activation, polymorphonuclear leucocytes (PMN) release bactericidal/permability-increasing protein, (BPI) from their azurophil granules. BPI selectively binds to the lipopolysaccharide (LPS) on gram-negat...

Irmeli Nupponen, Riikka Turunen, Timo Nevalainen, Heikki Peuravuori… in Pediatric Research (2002)

Article

Markers of Type I and Type III Collagen Turnover, Insulin-Like Growth Factors, and Their Binding Proteins in Cord Plasma of Small Premature Infants: Relationships with Fetal Growth, Gestational Age, Preeclampsia, and Antenatal Glucocorticoid Treatment

Disorders affecting fetal growth are commonly associated with premature birth. IGFs and their binding proteins (IGFBPs) are potent regulators of fetal growth. In vitro evidence suggests that they regulate collage...

Eero Kajantie, Timo Hytinantti, Riitta Koistinen, Juha Risteli… in Pediatric Research (2001)

Article

Cyclooxygenase-2 in Human Perinatal Lung

Cyclooxygenases-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostanoids. Cyclooxygenase-2 (COX-2) takes part both in inflammation and in control of cell growth. COX-2 immunohistochemi...

Patrik Lassus, Henrik Wolff, Sture Andersson in Pediatric Research (2000)