15 Result(s)

Article

A conditionally replication-defective cytomegalovirus vaccine elicits potent and diverse functional monoclonal antibodies in a phase I clinical trial

A conditionally replication-defective human cytomegalovirus (HCMV) vaccine, V160, was shown to be safe and immunogenic in a two-part, double-blind, randomized, placebo-controlled phase I clinical trial (NCT019...

Leike Li, Daniel C. Freed, Ya** Liu, Fengsheng Li, Diane F. Barrett… in npj Vaccines (2021)

Article

Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations

HCMV hyperimmunoglobulin-preparations (HIG) contain high concentrations of HCMV-specific IgG. The reduced maternofetal-HCMV-transmission rate of IgG may be due to HCMV-specific neutralizing antibodies against ...

Matthias Stefan Schampera, Jose Arellano-Galindo… in Medical Microbiology and Immunology (2019)

Article

Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination

Human cytomegalovirus (HCMV) is the leading cause of in utero viral infection in the United States. Since congenital HCMV infection can lead to birth defects in newborns, develo** a prophylactic vaccine is a...

Fengsheng Li, Daniel C. Freed, Aimin Tang, Richard R. Rustandi… in npj Vaccines (2017)

Article

Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo

Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised patients and a major cause of congenital birth defects when acquired in utero. In the 1990s, four chimeric viruses were ...

Nicolás M. Suárez, Betty Lau, George M. Kemble, Ronzo Lee… in Virus Genes (2017)

Article

Cytomegalovirus Infections among African-Americans

Since African-Americans have twice the prevalence of cytomegalovirus (CMV) infections as age-matched Caucasians we sought to determine the ages and possible sources of infection of African-American children.

Isca R Wilms, Al M Best, Stuart P Adler in BMC Infectious Diseases (2008)

Article

Lack of autoantibody production associated with cytomegalovirus infection

To confirm an association between cytomegalovirus (CMV) infection and the presence of antibodies to Smith (Sm), to ribonucleoprotein (RNP), and to a component of the U1 ribonucleoproteins (U1-70 kD), we measur...

Beth C Marshall, Richard A McPherson, Eric Greidinger… in Arthritis Research & Therapy (2002)

Article

MUCOSAL ANTIBODIES TO CYTOMEGALOVIRUS (CMV) GLYCOPROTEIN B (gB) OCCUR FOLLOWING BOTH NATURAL INFECTION AND IMMUNIZATION WITH CMV VACCINES.• 973

Stuart P Adler, Jian Ben Wang, Rae Lyn Burke, Ann-Marie Duliège… in Pediatric Research (1996)

Article

1044 DISTRIBUTION OF ANTIBODY AGAINST CYTOMEGALOVIRUS (CMV) IN THE FAMILIES OF TWINS

IgG against CMV was measured by enzyme immunoassay in 306 members of 71 monozygotic twin families including 135 children. 19% of children were seropositive (SP) compared to 46% of adults. 56% af mothers were S...

Stuart P Adler, Joann Bodurtha, Walter E Nance, H Maurer in Pediatric Research (1985)

Article

1046 THE DETECTION OF ANTIBODY AGAINST CYTOMEGALOVIRUS (CMV) USING LATEX AGGLUTINATION (LA)

Transfusion acquired CMV infections should be prevented for seronegative (SN) premature infants by providing blood products from SN donors. In order to provide laboratories with a very simple and rapid method ...

Stuart P Adler, David Marshall, Michael McVoy, Patricia Hider in Pediatric Research (1985)

Article

1043 A SIMPLE, RAPID, AND SENSITIVE METHOD FOR THE RESTRICTION ENDONUCLEASE ANALYSIS OF THE DNA OF CYTOMEGALOVIRUS (CMV)

Restriction enzyme analysis of CMV DNA is essential for investigating viral transmission. Previous methods for purifying DNA used either prolonged viral passage to obtain cell free virus and/or equilibrium cen...

Stuart P Adler, H Maurer in Pediatric Research (1985)

Article

1045 TRANSMISSION OF CYTOMEGALOVIRUS WITHIN A LARGE NEONATAL INTENSIVE CARE NURSERY

Acquired cytomegalovirus (CMV) infections are associated with significant morbidity and mortality for very low birthweight (LEW) infants, <1300gm, and infant-to-infant transmission has apparently occurred. The...

Stuart P Adler, Linda L Laurence, Mary S Wilson in Pediatric Research (1985)

Article

1047 CYTOMEGALOVIRUS TRANSMISSION AMONG CHILDREW ATTENDING A DAY CARE CENTER

Sixty-seven children, with a mean age of 30 months, attending a day care center had urine samples cultured for cytomegalovirus (CMV) 3 times over 6 months. Twenty-one children had CMV viruria. Viruria did not ...

Stuart P Adler, Mari S Wilson, Linda L Lawrence in Pediatric Research (1985)

Article

THE PREVALENCE OF CYTOMEGALOVIRUS (CMV) VIRURIA AMONG HOSPITALIZED CHILDREN AND THE RISK OF CMV ACQUISITION BY NURSES

In 17 months 2198 children had admission urines cultured for CMV. 4.7% had CMV viruria (105 positive cultures), but significant age differences were observed. In the intensive care nursery the prevalence of CM...

Stuart P Adler, Linda T Lawrence, Mary S Wilson in Pediatric Research (1984)