-
Article
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
Charles Swanton and colleagues used multiregion exome sequencing to study the evolutionary histories of ten clear cell renal cell carcinomas. They observed marked intratumoral heterogeneity in all cases, with ...
-
Article
Open AccessDevelopment of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution
Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution.
-
Article
Open AccessDeciphering clonality in aneuploid breast tumors using SNP array and sequencing data
Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numb...
-
Article
Open AccessRecurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes of 3...
-
Article
The Wilms Tumor-1 (WT1) rs2234593 variant is a prognostic factor in normal karyotype acute myeloid leukemia
The single-nucleotide polymorphism (SNP) within Wilms tumor-1 (WT1) exon 7, rs16754, has been arguably reported to be implicated in acute myeloid leukemia (AML) prognosis. We assessed the potential association of...
-
Article
Spatial heterogeneity in medulloblastoma
Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using a combination of transcriptomic and genomic profi...
-
Article
Metastatic-niche labelling reveals parenchymal cells with stem features
Direct investigation of the early cellular changes induced by metastatic cells within the surrounding tissue remains a challenge. Here we present a system in which metastatic cancer cells release a cell-penetr...
-
Article
Open AccessTuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Tuberculous meningitis (TBM) is the most severe form of TB with high rates of mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebrospinal fluid (CS...
-
Article
Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Neuronal programming by microbiota regulates intestinal physiology
Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence, and is often dysregulated in gastrointes...
-
Article
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressu...
-
Article
Open AccessYAP1/TAZ drives ependymoma-like tumour formation in mice
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditiona...
-
Article
Open AccessAuthor Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Pervasive chromosomal instability and karyotype order in tumour evolution
Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary ...
-
Article
Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability
Rewiring of cellular programmes in malignant cells generates cancer-specific vulnerabilities. Here, using an unbiased screening strategy aimed at identifying non-essential genes required by tumour cells to sus...
-
Article
Open AccessProteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein ...
-
Article
Selection of metastasis competent subclones in the tumour interior
The genetic evolutionary features of solid tumour growth are becoming increasingly well described, but the spatial and physical nature of subclonal growth remains unclear. Here, we utilize 102 macroscopic whol...
-
Article
Open AccessSpatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study
Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification i...
-
Article
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization
Radiotherapy is one of the most effective approaches to achieve tumor control in cancer patients, although healthy tissue injury due to off-target radiation exposure can occur. In this study, we used a model o...
-
Article
Author Correction: Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization
