-
Article
Open AccessCollaboratively charting the gene-to-phenotype network of human congenital heart defects
How to efficiently integrate the daily practice of molecular biologists, geneticists, and clinicians with the emerging computational strategies from systems biology is still much of an open question.
-
Article
Open AccessAn experimental loop design for the detection of constitutional chromosomal aberrations by array CGH
Comparative genomic hybridization microarrays for the detection of constitutional chromosomal aberrations is the application of microarray technology coming fastest into routine clinical application. Through g...
-
Article
Open AccessText-mining assisted regulatory annotation
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental an...
-
Chapter and Conference Paper
Interpreting Gene Profiles from Biomedical Literature Mining with Self Organizing Maps
We present an approach to interpret gene profiles derived from biomedical literature using Self Organizing Maps (SOMs). Comparison of different clustering algorithms shows that SOMs perform better in grou** ...
-
Article
Open AccessarrayCGHbase: an analysis platform for comparative genomic hybridization microarrays
The availability of the human genome sequence as well as the large number of physically accessible oligonucleotides, cDNA, and BAC clones across the entire genome has triggered and accelerated the use of sever...
-
Article
TXTGate: profiling gene groups with text-based information
We implemented a framework called TXTGate that combines literature indices of selected public biological resources in a flexible text-mining system designed towards the analysis of groups of genes. By means of...
