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  1. No Access

    Article

    A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

    Abrogation of ubiquitin/proteasome-dependent turnover of p53 is critical for its activation. UbL-UBA proteins, including human homolog of Rad23 (hHR23) proteins, may regulate proteasomal degradation of substra...

    Chrystelle Brignone, Kathleen E Bradley, Alexei F Kisselev, Steven R Grossman in Oncogene (2004)

  2. Article

    Open Access

    CtBP—a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma

    Ctbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) transcriptional program. In the “CKP” m...

    Ayesha T. Chawla, Kranthi Kumar Chougoni, Prashant J. Joshi… in Oncogenesis (2019)

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  3. Article

    Open Access

    Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

    There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpresse...

    Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Travis Mason… in Oncogenesis (2023)

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