Skip to main content

3 Result(s)

within Chrystelle Brignone Remove this filter

and

  1. Article

    Open Access

    First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity

    IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We report clinical and biological r...

    Chrystelle Brignone, Maya Gutierrez, Fawzia Mefti… in Journal of Translational Medicine (2010)

    Download PDF (1152 KB) View Article

  2. Article

    Open Access

    IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study

    LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-like immune enhancer with ma...

    Chrystelle Brignone, Caroline Grygar… in Journal of Immune Based Therapies and Vacc… (2007)

    Download PDF (495 KB) View Article

  3. No Access

    Article

    A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

    Abrogation of ubiquitin/proteasome-dependent turnover of p53 is critical for its activation. UbL-UBA proteins, including human homolog of Rad23 (hHR23) proteins, may regulate proteasomal degradation of substra...

    Chrystelle Brignone, Kathleen E Bradley, Alexei F Kisselev, Steven R Grossman in Oncogene (2004)