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Open AccessHigh-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that ca...
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Open AccessFOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respo...
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Open AccessSOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2
Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressiv...
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Article
Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial
Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma. Treatment of Nf1fl/fl;Postn-Cre mice with cabozantinib, an ...
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Article
Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma
Aberrant Myc expression plays a critical role in various tumors, including non-Hodgkin lymphoma (NHL). Myc-positive lymphoma is clinically aggressive, more resistant to chemotherapy, and associated with high m...
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Chapter
Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein
RB is a critical tumor suppressor targeted at high frequency in human cancers. As part of its mode of action RB participates in the regulation of DNA replication. In the absence of functional RB aberrant repli...
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Protocol
Analysis of RB Action in DNA Damage Checkpoint Response
Cell cycle checkpoints play a key role in maintaining genome stability by monitoring the order and integrity of cell division events. Checkpoints induced by DNA damage function to limit the propagation of pote...
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Protocol
Functional Analysis of the Antimitogenic Activity of Tumor Suppressors
Loss of tumor suppressors contributes to numerous cancer types. Many, but not all, proteins encoded by tumor suppressor genes have antiproliferative activity and halt cell-cycle progression. In this chapter, w...
