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Article
Open AccessProteome-Wide Identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes
Ribonucleoprotein complexes are composed of RNA, RNA-dependent proteins (RDPs) and RNA-binding proteins (RBPs), and play fundamental roles in RNA regulation. However, in the human malaria parasite, Plasmodium fal...
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Article
Open AccessDNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. H...
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Article
Open AccessPlasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium ...
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Article
Open AccessNovel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. Increasing evidence now suggests a major role for epi...
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Article
Open AccessBabesia duncani multi-omics identifies virulence factors and drug targets
Babesiosis is a malaria-like disease in humans and animals that is caused by Babesia species, which are tick-transmitted apicomplexan pathogens. Babesia duncani causes severe to lethal infection in humans, but de...
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Article
Open AccessFunctional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum
The RAP (RNA-binding domain abundant in Apicomplexans) protein family has been identified in various organisms. Despite expansion of this protein family in apicomplexan parasites, their main biological functio...
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Article
Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
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Article
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Transmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage necessary to infect the mosquito vecto...
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Genome-Wide Analysis of RNA–Protein Interactions in Plasmodium falciparum Using eCLIP-Seq
Over the last decades, identification of RNA–proteins complexes and their binding sites was challenging. Recently, techniques based on crosslinking, immunoprecipitation, and high-throughput sequencing have bee...
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Article
Open AccessWorldline theories with towers of internal states
We study particle theories that have a tower of worldline internal degrees of freedom. Such a theory can arise when the worldsheet of closed strings is dimensionally reduced to a worldline, in which case the t...
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Article
Open AccessNonlocal gravity with worldline inversion symmetry
We construct a quadratic curvature theory of gravity whose graviton propagator around the Minkowski background respects wordline inversion symmetry, the particle approximation to modular invariance in string t...
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Article
Open AccessBPS solutions for generalised Wess-Zumino models and their applications
We present BPS solutions to a general class of Wess-Zumino models which ex- tend previous results in the literature. We discuss their relation to amplitudes on threshold, and their application to scalar domain...
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Article
Open AccessStability and vacuum energy in open string models with broken supersymmetry
We construct type I string models with supersymmetry broken by compactifi- cation that are non-tachyonic and have exponentially small effective potential at one-loop. All open string moduli can be stabilized, ...
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Article
Open AccessUV completion on the worldline
A framework for UV completing particle theories is proposed, based on the worldline formalism, which is equivalent to weighting all sums over histories with a proper-time dependent measure that has a smallest ...
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Article
Open AccessA dynamical mechanism for large volumes with consistent couplings
A mechanism for addressing the “decompactification problem” is proposed, which consists of balancing the vacuum energy in Scherk-Schwarzed theories against contributions coming from non-perturbative physics. U...
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Article
Open AccessPhoto-production of a 750 GeV di-photon resonance mediated by Kaluza-Klein leptons in the loop
We consider the phenomenology of a 750 GeV resonance X which can be produced at the LHC by only photon fusion and subsequently decay into di-photons. We propose that the spin-zero state X is coupled to a heavy le...
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Article
Open AccessShift-symmetries at higher order
The fate of shift-symmetries in effective string models is considered beyond tree-level. Such symmetries have been proposed in the past as a way to maintain a hierarchically small Higgs mass and also play a ro...
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Article
Open AccessQ-branes
Non-topological solitons (Q-balls) are discussed in some stringy settings. Our main result is that the dielectric D-brane system of Myers admits non-abelian Q-ball solutions on their world-volume, in which N Dp-b...
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Article
Open AccessGenetic algorithms and the search for viable string vacua
Genetic Algorithms are introduced as a search method for finding string vacua with viable phenomenological properties. It is shown, by testing them against a class of Free Fermionic models, that they are order...
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Article
Open AccessNatural supersymmetry and dynamical flavour with meta-stable vacua
We show how gauged flavour breaking and N ...
