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Article
Open AccessAttitudes toward and training in medications for opioid use disorders: a descriptive analysis among employees in the youth legal system and community mental health centers
Research demonstrates gaps in medications for opioid use disorder uptake (MOUDs; methadone, buprenorphine, and naltrexone) especially among adolescents. These gaps may be partly attributable to attitudes about...
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Article
Open AccessEarly development of local data dashboards to depict the substance use care cascade for youth involved in the legal system: qualitative findings from end users
Rates of substance use are high among youth involved in the legal system (YILS); however, YILS are less likely to initiate and complete substance use treatment compared to their non legally-involved peers. The...
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Article
Open AccessRoughness and dynamics of proliferating cell fronts as a probe of cell–cell interactions
Juxtacellular interactions play an essential but still not fully understood role in both normal tissue development and tumour invasion. Using proliferating cell fronts as a model system, we explore the effects...
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Article
Open AccessAdenosine integrates light and sleep signalling for the regulation of circadian timing in mice
The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and indep...
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Protocol
Measuring Circadian Rhythms in Human Cells
Human cells, especially primary fibroblasts from skin punch biopsy, have emerged over the last decade as powerful, unlimited, and easily accessible resources that bridge the gap between animal models and human...
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Protocol
Circadian Metabolomics from Breath
Metabolites like melatonin are essential in determining circadian phase. In the recent years, comprehensive metabolome analyses have unveiled entire panels of small biomolecules fluctuating in a circadian fash...
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Chapter
Circadian Clocks, Sleep, and Metabolism
A molecular circadian clock exists not only in the brain, but also in most cells of the body. Research over the past two decades has demonstrated that it directs daily rhythmicity of nearly every aspect of met...
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Article
Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes
The circadian system plays an essential role in regulating the timing of human metabolism. Indeed, circadian misalignment is strongly associated with high rates of metabolic disorders. The properties of the ci...
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Chapter
Circadian Metabolomics: Insights for Biology and Medicine
A biological “circadian” clock governs nearly all aspects of mammalian behavior and physiology. This control extends from activities of entire organ systems down to individual cells, all of which contain auton...
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Chapter
RNA Dynamics in the Control of Circadian Rhythm
The circadian oscillator is based on transcription-translation feedback loops that generate 24 h oscillations in gene expression. Although circadian regulation of mRNA expression at the transcriptional level i...
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Article
Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects
Via exome sequencing, the authors identified mutations in the NONO protein, a member of the DBHS family, as a likely cause of severe intellectual disability. Using animal and cell models, they found that nearl...
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Article
Circadian behavior is light-reprogrammed by plastic DNA methylation
In this study, the authors show that altering the photoperiod of mice results in reversible transcriptional and DNA methylation changes in the suprachiasmatic nucleus. Application of a methyltransferase inhibi...
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Chapter
Adenosine and Other Purinergic Products in Circadian Timing
The circadian oscillator plays an important role in behavior and metabolic physiology. In turn, adenosine occupies a unique position as both a fundamental neuromodulator and a basic building block of cellular ...
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Chapter
Peripheral Circadian Oscillators in Mammals
Although circadian rhythms in mammalian physiology and behavior are dependent upon a biological clock in the suprachiasmatic nuclei (SCN) of the hypothalamus, the molecular mechanism of this clock is in fact c...
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Chapter
Studying Human Circadian Behaviour Using Peripheral Cells
Complex behaviours are the product of intercellular signalling events, but their intracellular effectors are present in most cell types. The best-studied example of such architecture is the circadian clock, wh...
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Chapter
Transcriptional Regulation of Circadian Clocks
Transcription is the first step necessary to utilize genetic information. The activation or repression of genes is highly regulated. Here, we will shed light on the connection between transcription and the cir...
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Article
Production of mummichog (Fundulus heteroclitus): Response in marshes treated for common reed (Phragmites australis) removal
The invasion of U.S. east coast salt marshes by common reed (Phragmites australis) and the efforts to remove it and restore marshes to their natural vegetation (Spartina spp.) can directly impact mummichog (Fundu...
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Article
The mammalian circadian timing system: from gene expression to physiology
Many physiological processes in organisms from bacteria to man are rhythmic, and some of these are controlled by self-sustained oscillators that persist in the absence of external time cues. Circadian clocks a...
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Chapter and Conference Paper
On the Development of a Finite Element Program for Microcomputers
In this paper the authors highlignt the hardware and software considerations which are crucial in the development of a reliable and meaninyful finite element proyram operational on a microcomputer. The three g...
