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Article
Open AccessCorrection: Preventing early childhood transmission of hepatitis B in remote Aboriginal communities in northern Australia
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Article
Open AccessPreventing early childhood transmission of hepatitis B in remote Aboriginal communities in northern Australia
Chronic hepatitis B is a public health concern in Aboriginal communities in the Northern Territory of Australia with prevalence almost four times the non-Aboriginal population. Infection is suspected to mainly...
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Article
Global strategies are required to cure and eliminate HBV infection
The many gaps in our knowledge and understanding of HBV infection hampers our ability to develop and achieve a cure on a global scale. In this Perspective, Fabien Zoulim and colleagues propose the development ...
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Article
Essential components in develo** public policy to control viral hepatitis: lessons from Taiwan
Over 500 million people are estimated to be infected with chronic viral hepatitis with an increasing burden resulting from the infections. In 2010, the World Health Organization recommended national government...
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Chapter
The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance, and Novel Small Molecule Inhibitors
Chronic hepatitis B affects over 300 million people globally, and although there is an effective preventative vaccine, there is no cure. The recent discovery of the NTCP entry receptor means that infection mod...
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Article
Open AccessComposition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy
Reverse transcriptase (RT) mutations contribute to hepatitis B virus resistance during antiviral therapy with nucleos(t)ide analogs. However, the composition of the RT quasispecies and their interactions durin...
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Article
Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype
Hepatitis B virus (HBV) can be classified into ten genotypes (A–J), with genotypes B and C being the most common in Asia. Recent data suggest that the HBV genotype can influence disease progression, and genoty...
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Article
Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update
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Article
Role of Resistance Testing During Oral Antiviral Therapy of Chronic Hepatitis B
Hepatitis B virus (HBV) DNA replication is an error prone mechanism and coupled with selection pressure from antiviral agents, emergence of resistance can be frequent. Antiviral drug resistance has been associ...
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Article
Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update
Large volume of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2008. These include further studies in asymptomatic subjects with chronic ...
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Article
Open AccessAssessment of HBV flare in a randomized clinical trial in HIV/HBV coinfected subjects initiating HBV-active antiretroviral therapy in Thailand
Hepatic Flare (HF) after initiation of highly active antiretroviral therapy (HAART) in HIV-HBV coinfected individuals is well recognized but prospective data on predictors and subsequent outcome are limited.
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Article
The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B
Chronic hepatitis B (CHB) remains a serious clinical problem worldwide. Advances in molecular technology have enabled the development of sensitive assays for the detection and quantification of hepatitis B vir...
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Article
Monitoring drug therapy for hepatitis B—a global challenge?
A new study has found undetectable serum levels of HBV DNA at week 24 of treatment to be the strongest predictor of optimal outcomes for patients with chronic HBV infection. Although this finding is not surpri...
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Chapter
The Hepatitis B Virus and Antiviral Drug Resistance: Causes, Patterns, and Mechanisms
This chapter will briefl y review the major aspects of the molecular virology and replication of HBV, and summarize the major viral mutants of clinical signifi cance that are associated with drug resistance. A...
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Article
Open AccessAsian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update
Large amounts of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2005. These include long-term follow-up studies in large community-based ...
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Article
Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure
Antiviral resistance is now the single most important factor in treatment failure using nucleos(t)ide analogues (NA). Primary drug resistance mutations refer to amino acid change(s) that result in reduced susc...
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Article
Introduction
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Chapter
Molecular Diagnostics in Hepatitis B
An estimated 400 million people are chronically infected with hepatitis B virus (HBV) and many will suffer serious liver disease as a consequence. HBV is an enveloped, partially double-stranded DNA virus, whic...
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Protocol
Monitoring Gene Expression Using DNA Microarrays During Hepatitis B Virus Infection
Under normal circumstances, hepatocyte infection with the hepatitis B virus (HBV) is noncytopathic. Hepatocellular damage is mediated by the cellular and humoral arms of the host’s immune system (1). The final cl...
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Protocol
Quantification of HBV Covalently Closed Circular DNA from Liver Tissue by Real-Time PCR
Hepadnaviruses utilize an unusual replication strategy. On infection, the partially double-stranded open circular genomic DNA is transported to the hepatocyte nucleus, where host-cell enzymes convert it to a r...
