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    Chapter

    IL-1 antagonist discovery

    Interleukin 1 (IL-1) is a pivotal pro-inflammatory cytokine involved in many types of inflammatory and autoimmune diseases [1]. IL-1 production whether initiated by infection or host antigen, initiates an inflamm...

    Terry L. Bowlin, Stephen D. Yanofsky in High Throughput Screening for Novel Anti-I… (2000)

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    Article

    A Generic Method for Expression and Use of “Tagged” Soluble Versions of Cell Surface Receptors

    A general method for expression, purification, immobilization, detection and radiolabeling of extracellular domains (ECD) of type I membrane proteins. The type I interleukin-1 receptor (IL-lRtI), the α-subunit...

    Erik A. Whitehorn, Emily Tate, Stephen D. Yanofsky, Lynn Kochersperger in Bio/Technology (1995)