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IL-1 antagonist discovery
Interleukin 1 (IL-1) is a pivotal pro-inflammatory cytokine involved in many types of inflammatory and autoimmune diseases [1]. IL-1 production whether initiated by infection or host antigen, initiates an inflamm...
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Article
A Generic Method for Expression and Use of “Tagged” Soluble Versions of Cell Surface Receptors
A general method for expression, purification, immobilization, detection and radiolabeling of extracellular domains (ECD) of type I membrane proteins. The type I interleukin-1 receptor (IL-lRtI), the α-subunit...