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Article
Open AccessGenome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed DNAm in 344 samples of human postm...
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Article
Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers
Numerous DNA methylation (DNAm) biomarkers of cigarette smoking have been identified in peripheral blood studies, but because of tissue specificity, blood-based studies may not detect brain-specific smoking-re...
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Article
Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome
Cigarette smoking during pregnancy is a major public health concern. While there are well-described consequences in early child development, there is very little known about the effects of maternal smoking on ...
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Article
Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)
Genome-wide association studies (GWAS) have identified many genomic loci associated with risk for schizophrenia, but unambiguous identification of the relationship between disease-associated variants and speci...
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Article
Open AccessDissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lin...
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Article
Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease
Late-onset Alzheimer’s disease (AD) is a complex age-related neurodegenerative disorder that likely involves epigenetic factors. To better understand the epigenetic state associated with AD, we surveyed 420,85...