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Article
Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression
Splice modulators have been assessed clinically in treating haematologic malignancies exhibiting splice factor mutations and acute myeloid leukaemia. However, the mechanisms by which such modulators repress le...
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Article
Increasing genomic discovery in newly diagnosed multiple myeloma: defining disease biology and its correlation to risk
Our understanding of MM genomics has expanded rapidly in the past 5–10 years as a consequence of cytogenetic analyses obtained in routine clinical practice as well as the ability to perform whole-exome/genome ...
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Article
Neurological Complications of the Leukemias Across the Ages
Acute and chronic leukemias are heterogeneous diseases and can affect any part of the body upon initial discovery. Understanding the sequela of systemic involvement is key for proper diagnosis and treatment.